| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf198 | LGALSL | ENSP00000355623 | ENSP00000238875 | Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.589 |
| CD101 | IGSF1 | ENSP00000358482 | ENSP00000359940 | Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marke [...] | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription; Immunoglobulin like domain containing | 0.802 |
| CD101 | LGALSL | ENSP00000358482 | ENSP00000238875 | Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marke [...] | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.654 |
| CEP68 | COMMD1 | ENSP00000367229 | ENSP00000308236 | Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitin [...] | 0.675 |
| CEP68 | LGALSL | ENSP00000367229 | ENSP00000238875 | Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.727 |
| COMMD1 | CEP68 | ENSP00000308236 | ENSP00000367229 | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitin [...] | Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase | 0.675 |
| COMMD1 | LGALSL | ENSP00000308236 | ENSP00000238875 | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitin [...] | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.483 |
| EVA1C | LGALSL | ENSP00000300255 | ENSP00000238875 | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.586 |
| FAM13C | LGALSL | ENSP00000481854 | ENSP00000238875 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.521 |
| FAM213B | LGALSL | ENSP00000413218 | ENSP00000238875 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity); Belongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.672 |
| GALM | LGALSL | ENSP00000272252 | ENSP00000238875 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.630 |
| ICT1 | LGALSL | ENSP00000301585 | ENSP00000238875 | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.532 |
| IGSF1 | CD101 | ENSP00000359940 | ENSP00000358482 | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription; Immunoglobulin like domain containing | Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marke [...] | 0.802 |
| IGSF1 | LGALSL | ENSP00000359940 | ENSP00000238875 | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription; Immunoglobulin like domain containing | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | 0.667 |
| LGALSL | C1orf198 | ENSP00000238875 | ENSP00000355623 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198 | 0.589 |
| LGALSL | CD101 | ENSP00000238875 | ENSP00000358482 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marke [...] | 0.654 |
| LGALSL | CEP68 | ENSP00000238875 | ENSP00000367229 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase | 0.727 |
| LGALSL | COMMD1 | ENSP00000238875 | ENSP00000308236 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitin [...] | 0.483 |
| LGALSL | EVA1C | ENSP00000238875 | ENSP00000300255 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family | 0.586 |
| LGALSL | FAM13C | ENSP00000238875 | ENSP00000481854 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family | 0.521 |
