| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CMPK2 | IFI27L2 | ENSP00000256722 | ENSP00000238609 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | Interferon alpha inducible protein 27 like 2 | 0.496 |
| CMPK2 | RSAD2 | ENSP00000256722 | ENSP00000371471 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the [...] | 0.967 |
| CMPK2 | USP18 | ENSP00000256722 | ENSP00000215794 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms; Ubiquitin specific peptidases | 0.707 |
| DNAJC5B | IFI27L2 | ENSP00000276570 | ENSP00000238609 | DnaJ heat shock protein family member C5 beta | Interferon alpha inducible protein 27 like 2 | 0.420 |
| IFI27L2 | CMPK2 | ENSP00000238609 | ENSP00000256722 | Interferon alpha inducible protein 27 like 2 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | 0.496 |
| IFI27L2 | DNAJC5B | ENSP00000238609 | ENSP00000276570 | Interferon alpha inducible protein 27 like 2 | DnaJ heat shock protein family member C5 beta | 0.420 |
| IFI27L2 | ITLN2 | ENSP00000238609 | ENSP00000357008 | Interferon alpha inducible protein 27 like 2 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.425 |
| IFI27L2 | OLFML1 | ENSP00000238609 | ENSP00000332511 | Interferon alpha inducible protein 27 like 2 | Olfactomedin-like protein 1; Olfactomedin like 1 | 0.516 |
| IFI27L2 | RPS15A | ENSP00000238609 | ENSP00000318646 | Interferon alpha inducible protein 27 like 2 | Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family | 0.416 |
| IFI27L2 | RSAD2 | ENSP00000238609 | ENSP00000371471 | Interferon alpha inducible protein 27 like 2 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the [...] | 0.458 |
| IFI27L2 | STC2 | ENSP00000238609 | ENSP00000265087 | Interferon alpha inducible protein 27 like 2 | Stanniocalcin-2; Has an anti-hypocalcemic action on calcium and phosphate homeostasis; Belongs to the stanniocalcin family | 0.427 |
| IFI27L2 | TMEM168 | ENSP00000238609 | ENSP00000323068 | Interferon alpha inducible protein 27 like 2 | Transmembrane protein 168; Belongs to the TMEM168 family | 0.565 |
| IFI27L2 | UBE2L6 | ENSP00000238609 | ENSP00000287156 | Interferon alpha inducible protein 27 like 2 | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3; Ubiquitin conjugating enzymes E2 | 0.498 |
| IFI27L2 | USP18 | ENSP00000238609 | ENSP00000215794 | Interferon alpha inducible protein 27 like 2 | Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms; Ubiquitin specific peptidases | 0.441 |
| ITLN2 | IFI27L2 | ENSP00000357008 | ENSP00000238609 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Interferon alpha inducible protein 27 like 2 | 0.425 |
| OLFML1 | IFI27L2 | ENSP00000332511 | ENSP00000238609 | Olfactomedin-like protein 1; Olfactomedin like 1 | Interferon alpha inducible protein 27 like 2 | 0.516 |
| OLFML1 | TMEM168 | ENSP00000332511 | ENSP00000323068 | Olfactomedin-like protein 1; Olfactomedin like 1 | Transmembrane protein 168; Belongs to the TMEM168 family | 0.775 |
| RPS15A | IFI27L2 | ENSP00000318646 | ENSP00000238609 | Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family | Interferon alpha inducible protein 27 like 2 | 0.416 |
| RSAD2 | CMPK2 | ENSP00000371471 | ENSP00000256722 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the [...] | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | 0.967 |
| RSAD2 | IFI27L2 | ENSP00000371471 | ENSP00000238609 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the [...] | Interferon alpha inducible protein 27 like 2 | 0.458 |
