| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACYP1 | ADCK1 | ENSP00000238618 | ENSP00000238561 | Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.556 |
| ACYP1 | TMTC3 | ENSP00000238618 | ENSP00000266712 | Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.566 |
| ADCK1 | ACYP1 | ENSP00000238561 | ENSP00000238618 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family | 0.556 |
| ADCK1 | C14orf178 | ENSP00000238561 | ENSP00000348145 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 | 0.585 |
| ADCK1 | CDKL3 | ENSP00000238561 | ENSP00000265334 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | 0.552 |
| ADCK1 | COQ3 | ENSP00000238561 | ENSP00000254759 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family | 0.781 |
| ADCK1 | COQ6 | ENSP00000238561 | ENSP00000333946 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3- polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 | 0.712 |
| ADCK1 | COQ7 | ENSP00000238561 | ENSP00000322316 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner; Belongs to the COQ7 family | 0.726 |
| ADCK1 | COQ9 | ENSP00000238561 | ENSP00000262507 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7 | 0.626 |
| ADCK1 | NOXRED1 | ENSP00000238561 | ENSP00000370215 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase | 0.668 |
| ADCK1 | SAMD15 | ENSP00000238561 | ENSP00000216471 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Sterile alpha motif domain containing 15 | 0.556 |
| ADCK1 | TMTC3 | ENSP00000238561 | ENSP00000266712 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.601 |
| C14orf178 | ADCK1 | ENSP00000348145 | ENSP00000238561 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.585 |
| C14orf178 | NOXRED1 | ENSP00000348145 | ENSP00000370215 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase | 0.765 |
| C14orf178 | SAMD15 | ENSP00000348145 | ENSP00000216471 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 | Sterile alpha motif domain containing 15 | 0.679 |
| CDKL3 | ADCK1 | ENSP00000265334 | ENSP00000238561 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.552 |
| COQ3 | ADCK1 | ENSP00000254759 | ENSP00000238561 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.781 |
| COQ3 | COQ6 | ENSP00000254759 | ENSP00000333946 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3- polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 | 0.997 |
| COQ3 | COQ7 | ENSP00000254759 | ENSP00000322316 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner; Belongs to the COQ7 family | 0.996 |
| COQ3 | COQ9 | ENSP00000254759 | ENSP00000262507 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7 | 0.956 |
