| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | CCNI | ENSP00000360268 | ENSP00000237654 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Cyclin-I; Cyclin I; Belongs to the cyclin family | 0.731 |
| ALDH18A1 | CDC6 | ENSP00000360268 | ENSP00000209728 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.446 |
| CCNI | ALDH18A1 | ENSP00000237654 | ENSP00000360268 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.731 |
| CCNI | CDC6 | ENSP00000237654 | ENSP00000209728 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.558 |
| CCNI | CDK16 | ENSP00000237654 | ENSP00000276052 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.611 |
| CCNI | CDK2 | ENSP00000237654 | ENSP00000266970 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.551 |
| CCNI | CDK5 | ENSP00000237654 | ENSP00000419782 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | 0.625 |
| CCNI | ENSG00000272772 | ENSP00000237654 | ENSP00000430774 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Uncharacterized protein; Belongs to the SKP1 family | 0.673 |
| CCNI | MTL5 | ENSP00000237654 | ENSP00000255087 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family | 0.541 |
| CCNI | PCNXL4 | ENSP00000237654 | ENSP00000317396 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Pecanex-like 4 (Drosophila); Belongs to the pecanex family | 0.526 |
| CCNI | SCAPER | ENSP00000237654 | ENSP00000454973 | Cyclin-I; Cyclin I; Belongs to the cyclin family | S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm; Zinc fingers C2H2-type | 0.583 |
| CCNI | TSSK3 | ENSP00000237654 | ENSP00000362634 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.645 |
| CDC6 | ALDH18A1 | ENSP00000209728 | ENSP00000360268 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.446 |
| CDC6 | CCNI | ENSP00000209728 | ENSP00000237654 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-I; Cyclin I; Belongs to the cyclin family | 0.558 |
| CDC6 | CDK16 | ENSP00000209728 | ENSP00000276052 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.720 |
| CDC6 | CDK2 | ENSP00000209728 | ENSP00000266970 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.999 |
| CDC6 | ENSG00000272772 | ENSP00000209728 | ENSP00000430774 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Uncharacterized protein; Belongs to the SKP1 family | 0.455 |
| CDK16 | CCNI | ENSP00000276052 | ENSP00000237654 | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Cyclin-I; Cyclin I; Belongs to the cyclin family | 0.611 |
| CDK16 | CDC6 | ENSP00000276052 | ENSP00000209728 | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.720 |
| CDK16 | CDK5 | ENSP00000276052 | ENSP00000419782 | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | 0.436 |
