| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAMP | MMADHC | ENSP00000248450 | ENSP00000389060 | Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC | 0.613 |
| AAMP | PMFBP1 | ENSP00000248450 | ENSP00000237353 | Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | 0.613 |
| ELMOD2 | MTUS1 | ENSP00000326342 | ENSP00000262102 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | 0.588 |
| ELMOD2 | PMFBP1 | ENSP00000326342 | ENSP00000237353 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | 0.605 |
| ELMOD2 | SPATA4 | ENSP00000326342 | ENSP00000280191 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.494 |
| MMADHC | AAMP | ENSP00000389060 | ENSP00000248450 | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC | Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing | 0.613 |
| MMADHC | PMFBP1 | ENSP00000389060 | ENSP00000237353 | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | 0.613 |
| MTUS1 | ELMOD2 | ENSP00000262102 | ENSP00000326342 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | 0.588 |
| MTUS1 | PMFBP1 | ENSP00000262102 | ENSP00000237353 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | 0.690 |
| MTUS1 | SPATA4 | ENSP00000262102 | ENSP00000280191 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.669 |
| PMFBP1 | AAMP | ENSP00000237353 | ENSP00000248450 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing | 0.613 |
| PMFBP1 | ELMOD2 | ENSP00000237353 | ENSP00000326342 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | 0.605 |
| PMFBP1 | MMADHC | ENSP00000237353 | ENSP00000389060 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC | 0.613 |
| PMFBP1 | MTUS1 | ENSP00000237353 | ENSP00000262102 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | 0.690 |
| PMFBP1 | SEC61A2 | ENSP00000237353 | ENSP00000298428 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity); Belongs to the SecY/SEC61-alpha family | 0.578 |
| PMFBP1 | SGIP1 | ENSP00000237353 | ENSP00000360076 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | SH3-containing GRB2-like protein 3-interacting protein 1; May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis | 0.682 |
| PMFBP1 | SPATA4 | ENSP00000237353 | ENSP00000280191 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.618 |
| PMFBP1 | TDRD5 | ENSP00000237353 | ENSP00000406052 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity); Tudor domain containing | 0.605 |
| PMFBP1 | YTHDF3 | ENSP00000237353 | ENSP00000478490 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context. Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome sub [...] | 0.659 |
| PMFBP1 | ZNF821 | ENSP00000237353 | ENSP00000398089 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.619 |
