| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAH1 | CST3 | ENSP00000371152 | ENSP00000381448 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | 0.904 |
| ASAH1 | CSTB | ENSP00000371152 | ENSP00000291568 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | 0.904 |
| ASAH1 | CTSD | ENSP00000371152 | ENSP00000236671 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.941 |
| ASAH1 | CTSH | ENSP00000371152 | ENSP00000220166 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | 0.906 |
| ASAH1 | CTSS | ENSP00000371152 | ENSP00000357981 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins | 0.914 |
| ASAH1 | MMP9 | ENSP00000371152 | ENSP00000361405 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide; M10 matrix metallopeptidases | 0.911 |
| CST3 | ASAH1 | ENSP00000381448 | ENSP00000371152 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | 0.904 |
| CST3 | CSTB | ENSP00000381448 | ENSP00000291568 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | 0.979 |
| CST3 | CTSB | ENSP00000381448 | ENSP00000345672 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.859 |
| CST3 | CTSD | ENSP00000381448 | ENSP00000236671 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.972 |
| CST3 | CTSH | ENSP00000381448 | ENSP00000220166 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | 0.955 |
| CST3 | CTSS | ENSP00000381448 | ENSP00000357981 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins | 0.960 |
| CST3 | MMP9 | ENSP00000381448 | ENSP00000361405 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | Matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide; M10 matrix metallopeptidases | 0.939 |
| CSTB | ASAH1 | ENSP00000291568 | ENSP00000371152 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | 0.904 |
| CSTB | CST3 | ENSP00000291568 | ENSP00000381448 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | 0.979 |
| CSTB | CTSB | ENSP00000291568 | ENSP00000345672 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.829 |
| CSTB | CTSD | ENSP00000291568 | ENSP00000236671 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.964 |
| CSTB | CTSH | ENSP00000291568 | ENSP00000220166 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | 0.980 |
| CSTB | CTSS | ENSP00000291568 | ENSP00000357981 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins | 0.937 |
| CSTB | CTSZ | ENSP00000291568 | ENSP00000217131 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity; Cathepsins | 0.464 |
