node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPTL1 | BAI2 | ENSP00000234816 | ENSP00000362759 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity) | 0.501 |
ANGPTL1 | C19orf80 | ENSP00000234816 | ENSP00000479969 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.726 |
ANGPTL1 | FAM20B | ENSP00000234816 | ENSP00000263733 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | 0.645 |
ANGPTL1 | LMOD1 | ENSP00000234816 | ENSP00000356257 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family | 0.487 |
ANGPTL1 | LPL | ENSP00000234816 | ENSP00000309757 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.533 |
ANGPTL1 | MEP1A | ENSP00000234816 | ENSP00000230588 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Meprin A subunit alpha; Belongs to the peptidase M12A family | 0.485 |
ANGPTL1 | PROX2 | ENSP00000234816 | ENSP00000451223 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity); Belongs to the Prospero homeodomain family | 0.550 |
ANGPTL1 | RALGPS2 | ENSP00000234816 | ENSP00000356607 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | 0.714 |
ANGPTL1 | TEK | ENSP00000234816 | ENSP00000369375 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inhibits ang [...] | 0.775 |
ANGPTL1 | TIE1 | ENSP00000234816 | ENSP00000361554 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis | 0.755 |
BAI2 | ANGPTL1 | ENSP00000362759 | ENSP00000234816 | Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity) | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.501 |
C19orf80 | ANGPTL1 | ENSP00000479969 | ENSP00000234816 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.726 |
C19orf80 | LPL | ENSP00000479969 | ENSP00000309757 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.964 |
FAM20B | ANGPTL1 | ENSP00000263733 | ENSP00000234816 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.645 |
FAM20B | RALGPS2 | ENSP00000263733 | ENSP00000356607 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | 0.719 |
LMOD1 | ANGPTL1 | ENSP00000356257 | ENSP00000234816 | Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.487 |
LPL | ANGPTL1 | ENSP00000309757 | ENSP00000234816 | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.533 |
LPL | C19orf80 | ENSP00000309757 | ENSP00000479969 | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.964 |
MEP1A | ANGPTL1 | ENSP00000230588 | ENSP00000234816 | Meprin A subunit alpha; Belongs to the peptidase M12A family | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.485 |
PROX2 | ANGPTL1 | ENSP00000451223 | ENSP00000234816 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity); Belongs to the Prospero homeodomain family | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like | 0.550 |