• Version:
  • 11.0 [archived version]
STRINGSTRING
HCN2 HCN2 CPA4 CPA4 TPSG1 TPSG1 NMU NMU CPA3 CPA3 POTEI POTEI
"TPSG1" - Tryptase gamma in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPSG1Tryptase gamma; Serine proteases (321 aa)    
Predicted Functional Partners:
HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity); Cyclic nucleotide gated channels (889 aa)
     
        0.675
CPA3
M14 carboxypeptidases (417 aa)
       
 
  0.516
CPA4
Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family (421 aa)
       
 
  0.506
NMU
Neuromedin-U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder; Belongs to the NmU family (174 aa)
           
  0.473
POTEI
POTE ankyrin domain family member I; In the N-terminal section; belongs to the POTE family (1075 aa)
           
  0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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