node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL1 | DLX2 | ENSP00000266744 | ENSP00000234198 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | 0.758 |
ASCL1 | GAD1 | ENSP00000266744 | ENSP00000350928 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.583 |
ASCL1 | LHX6 | ENSP00000266744 | ENSP00000377854 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity); LIM class homeoboxes | 0.597 |
ASCL1 | MEIS2 | ENSP00000266744 | ENSP00000453793 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | 0.436 |
ASCL1 | NEUROG2 | ENSP00000266744 | ENSP00000317333 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.922 |
ASCL1 | OLIG2 | ENSP00000266744 | ENSP00000331040 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity); Basic helix-loop-helix proteins | 0.848 |
ASCL1 | SOX9 | ENSP00000266744 | ENSP00000245479 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | Transcription factor SOX-9; Transcriptional regulator. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Important for normal skeletal development; SRY-boxes | 0.516 |
ASCL1 | TBR1 | ENSP00000266744 | ENSP00000374205 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes | 0.601 |
DLX2 | ASCL1 | ENSP00000234198 | ENSP00000266744 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | 0.758 |
DLX2 | GAD1 | ENSP00000234198 | ENSP00000350928 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.682 |
DLX2 | IRX1 | ENSP00000234198 | ENSP00000305244 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Iroquois-class homeodomain protein IRX-1; TALE class homeoboxes and pseudogenes | 0.789 |
DLX2 | LHX6 | ENSP00000234198 | ENSP00000377854 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity); LIM class homeoboxes | 0.734 |
DLX2 | LMCD1 | ENSP00000234198 | ENSP00000157600 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway; LIM domain containing | 0.712 |
DLX2 | MEIS2 | ENSP00000234198 | ENSP00000453793 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | 0.652 |
DLX2 | NEUROG2 | ENSP00000234198 | ENSP00000317333 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.689 |
DLX2 | OLIG2 | ENSP00000234198 | ENSP00000331040 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity); Basic helix-loop-helix proteins | 0.673 |
DLX2 | SOX9 | ENSP00000234198 | ENSP00000245479 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | Transcription factor SOX-9; Transcriptional regulator. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Important for normal skeletal development; SRY-boxes | 0.663 |
DLX2 | TBR1 | ENSP00000234198 | ENSP00000374205 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes | 0.687 |
GAD1 | ASCL1 | ENSP00000350928 | ENSP00000266744 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation- acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5’-CANNTG-3’) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mos [...] | 0.583 |
GAD1 | DLX2 | ENSP00000350928 | ENSP00000234198 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; NKL subclass homeoboxes and pseudogenes | 0.682 |