| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBFA2T3 | ZBTB47 | ENSP00000268679 | ENSP00000232974 | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.666 |
| CEPT1 | ZBTB47 | ENSP00000441980 | ENSP00000232974 | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.437 |
| FBXO9 | ZBTB47 | ENSP00000244426 | ENSP00000232974 | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTO [...] | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.499 |
| HOOK2 | ZBTB47 | ENSP00000380785 | ENSP00000232974 | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.524 |
| KRI1 | ZBTB47 | ENSP00000320917 | ENSP00000232974 | KRI1 homolog; Belongs to the KRI1 family | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.486 |
| OAZ2 | ZBTB47 | ENSP00000463013 | ENSP00000232974 | Ornithine decarboxylase antizyme 2; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity) | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.473 |
| SEC22C | SS18L2 | ENSP00000264454 | ENSP00000401115 | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | 0.543 |
| SEC22C | TMEM89 | ENSP00000264454 | ENSP00000329557 | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs | Transmembrane protein 89 | 0.440 |
| SEC22C | ZBTB47 | ENSP00000264454 | ENSP00000232974 | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.534 |
| SS18L2 | SEC22C | ENSP00000401115 | ENSP00000264454 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs | 0.543 |
| SS18L2 | TMEM89 | ENSP00000401115 | ENSP00000329557 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | Transmembrane protein 89 | 0.473 |
| SS18L2 | ZBTB47 | ENSP00000401115 | ENSP00000232974 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.566 |
| TMEM89 | SEC22C | ENSP00000329557 | ENSP00000264454 | Transmembrane protein 89 | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs | 0.440 |
| TMEM89 | SS18L2 | ENSP00000329557 | ENSP00000401115 | Transmembrane protein 89 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | 0.473 |
| TMEM89 | ZBTB47 | ENSP00000329557 | ENSP00000232974 | Transmembrane protein 89 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.447 |
| ZBTB47 | CBFA2T3 | ENSP00000232974 | ENSP00000268679 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | 0.666 |
| ZBTB47 | CEPT1 | ENSP00000232974 | ENSP00000441980 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family | 0.437 |
| ZBTB47 | FBXO9 | ENSP00000232974 | ENSP00000244426 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTO [...] | 0.499 |
| ZBTB47 | HOOK2 | ENSP00000232974 | ENSP00000380785 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | 0.524 |
| ZBTB47 | KRI1 | ENSP00000232974 | ENSP00000320917 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | KRI1 homolog; Belongs to the KRI1 family | 0.486 |
