KLHL18 protein (human) - STRING database

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KLHL18

Kelch-like protein 18; Kelch like family member 18; BTB domain containing (574 aa)

Predicted Functional Partners:

USP42

0.809

CUL3

0.718

TRAM2

0.703

ZBTB6

0.687

EEF1G

0.686

GPKOW

0.669

DHX16

0.668

CCDC12

0.635

PPIL4

0.619

TBRG4

0.584

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC12	KLHL18	ENSP00000292314	ENSP00000232766	Coiled-coil domain containing 12; Spliceosomal Bact complex	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	0.635
CUL3	KLHL18	ENSP00000264414	ENSP00000232766	Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...]	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	0.718
DHX16	GPKOW	ENSP00000365625	ENSP00000156109	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	G-patch domain and KOW motifs	0.996
DHX16	KLHL18	ENSP00000365625	ENSP00000232766	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	0.668
DHX16	PPIL4	ENSP00000365625	ENSP00000253329	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily	0.966
EEF1G	KLHL18	ENSP00000331901	ENSP00000232766	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	0.686
GPKOW	DHX16	ENSP00000156109	ENSP00000365625	G-patch domain and KOW motifs	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	0.996
GPKOW	KLHL18	ENSP00000156109	ENSP00000232766	G-patch domain and KOW motifs	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	0.669
GPKOW	PPIL4	ENSP00000156109	ENSP00000253329	G-patch domain and KOW motifs	Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily	0.963
KLHL18	CCDC12	ENSP00000232766	ENSP00000292314	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Coiled-coil domain containing 12; Spliceosomal Bact complex	0.635
KLHL18	CUL3	ENSP00000232766	ENSP00000264414	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...]	0.718
KLHL18	DHX16	ENSP00000232766	ENSP00000365625	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	0.668
KLHL18	EEF1G	ENSP00000232766	ENSP00000331901	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components	0.686
KLHL18	GPKOW	ENSP00000232766	ENSP00000156109	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	G-patch domain and KOW motifs	0.669
KLHL18	PPIL4	ENSP00000232766	ENSP00000253329	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily	0.619
KLHL18	TBRG4	ENSP00000232766	ENSP00000258770	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Protein TBRG4; May play a role in cell cycle progression; FASTK mitochondrial RNA binding family	0.584
KLHL18	TRAM2	ENSP00000232766	ENSP00000182527	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT); TLC domain containing	0.703
KLHL18	USP42	ENSP00000232766	ENSP00000301962	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Ubiquitin carboxyl-terminal hydrolase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis; Ubiquitin specific peptidases	0.809
KLHL18	ZBTB6	ENSP00000232766	ENSP00000362763	Kelch-like protein 18; Kelch like family member 18; BTB domain containing	Zinc finger and BTB domain-containing protein 6; May be involved in transcriptional regulation; BTB domain containing	0.687
PPIL4	DHX16	ENSP00000253329	ENSP00000365625	Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily	0.966

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