| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAA1 | ACAA2 | ENSP00000333664 | ENSP00000285093 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.843 |
| ACAA1 | ACADM | ENSP00000333664 | ENSP00000359871 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 0.975 |
| ACAA1 | ACOX1 | ENSP00000333664 | ENSP00000293217 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA | 0.991 |
| ACAA1 | ACOX2 | ENSP00000333664 | ENSP00000307697 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids; Belongs to the acyl-CoA oxidase family | 0.808 |
| ACAA1 | ACOX3 | ENSP00000333664 | ENSP00000348775 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids; Belongs to the acyl-CoA oxidase family | 0.969 |
| ACAA1 | EHHADH | ENSP00000333664 | ENSP00000231887 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family | 0.981 |
| ACAA1 | HADHB | ENSP00000333664 | ENSP00000325136 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | 0.842 |
| ACAA1 | HSD17B4 | ENSP00000333664 | ENSP00000420914 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.998 |
| ACAA1 | PECR | ENSP00000333664 | ENSP00000265322 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity; Short chain dehydrogenase/reductase superfamily | 0.626 |
| ACAA2 | ACAA1 | ENSP00000285093 | ENSP00000333664 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.843 |
| ACAA2 | ACADM | ENSP00000285093 | ENSP00000359871 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 0.996 |
| ACAA2 | ACOX1 | ENSP00000285093 | ENSP00000293217 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA | 0.960 |
| ACAA2 | ACOX3 | ENSP00000285093 | ENSP00000348775 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids; Belongs to the acyl-CoA oxidase family | 0.939 |
| ACAA2 | EHHADH | ENSP00000285093 | ENSP00000231887 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family | 0.977 |
| ACAA2 | HADHB | ENSP00000285093 | ENSP00000325136 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | 0.925 |
| ACAA2 | HSD17B4 | ENSP00000285093 | ENSP00000420914 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.509 |
| ACADM | ACAA1 | ENSP00000359871 | ENSP00000333664 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.975 |
| ACADM | ACAA2 | ENSP00000359871 | ENSP00000285093 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.996 |
| ACADM | ACOX1 | ENSP00000359871 | ENSP00000293217 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA | 0.956 |
| ACADM | ACOX2 | ENSP00000359871 | ENSP00000307697 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids; Belongs to the acyl-CoA oxidase family | 0.551 |
