• Version:
  • 11.0 [archived version]
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KRTCAP3 KRTCAP3 KRTAP15-1 KRTAP15-1 KRTAP27-1 KRTAP27-1 KRTAP4-1 KRTAP4-1 KRTAP26-1 KRTAP26-1 C5orf15 C5orf15 AMMECR1 AMMECR1 TMCO3 TMCO3 FIBCD1 FIBCD1 NLE1 NLE1 TMTC4 TMTC4
"C5orf15" - Keratinocyte-associated transmembrane protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C5orf15Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 (265 aa)    
Predicted Functional Partners:
TMCO3
Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family (677 aa)
           
  0.637
TMTC4
Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family (760 aa)
           
  0.563
FIBCD1
Fibrinogen C domain-containing protein 1; Acetyl group-binding receptor which shows a high- affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components; Fibrinogen C domain containing (461 aa)
           
  0.552
AMMECR1
AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 (333 aa)
           
  0.534
NLE1
Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity); Belongs to the NLE1/RSA4 family (485 aa)
           
  0.532
KRTAP27-1
Keratin-associated protein 27-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (207 aa)
           
  0.520
KRTAP26-1
Keratin-associated protein 26-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the PMG family (210 aa)
           
  0.513
KRTAP4-1
Keratin-associated protein 4-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family (146 aa)
           
  0.509
KRTAP15-1
Keratin-associated protein 15-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (137 aa)
           
  0.504
KRTCAP3
Keratinocyte associated protein 3 (240 aa)
           
  0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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