• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM140 TMEM140 SLITRK4 SLITRK4 CHD6 CHD6 STK32A STK32A GXYLT2 GXYLT2 PCDH12 PCDH12 LRIG3 LRIG3 GCM1 GCM1 PCDH17 PCDH17 PRL PRL FCGR1A FCGR1A
"PCDH12" - Protocadherin-12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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Cooccurence
Coexpression
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[Homology]
Score
PCDH12Protocadherin-12; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity); Non-clustered protocadherins (1184 aa)    
Predicted Functional Partners:
PCDH17
Protocadherin-17; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins (1159 aa)
       
 
0.812
CHD6
Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2; Myb/SANT domain containing (2715 aa)
       
 
  0.634
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing (1119 aa)
           
  0.599
FCGR1A
High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses; Belongs to the immunoglobulin superfamily. FCGR1 family (374 aa)
     
      0.570
SLITRK4
SLIT and NTRK-like protein 4; It is involved in synaptogenesis and promotes synapse differentiation. Suppresses neurite outgrowth (By similarity); Belongs to the SLITRK family (837 aa)
           
  0.566
STK32A
Serine/threonine kinase 32A (407 aa)
           
  0.558
GCM1
Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (436 aa)
           
  0.549
GXYLT2
Glucoside xylosyltransferase 2; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose; Glycosyltransferase family 8 (443 aa)
           
  0.537
TMEM140
Transmembrane protein 140 (185 aa)
           
  0.534
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family (227 aa)
           
  0.504
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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