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  • 11.0 [archived version]
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TTC1 TTC1 SLU7 SLU7 ATP10B ATP10B UBLCP1 UBLCP1 ELMOD1 ELMOD1 THG1L THG1L HARS2 HARS2 SOX30 SOX30 HARS HARS ADAM19 ADAM19 NSUN2 NSUN2
"THG1L" - Probable tRNA(His) guanylyltransferase in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
THG1LProbable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (298 aa)    
Predicted Functional Partners:
HARS
Histidine--tRNA ligase, cytoplasmic; Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance; Aminoacyl tRNA synthetases, Class II (509 aa)
     
 
  0.793
NSUN2
tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (767 aa)
     
 
  0.694
HARS2
Probable histidine--tRNA ligase, mitochondrial; histidyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class II (506 aa)
     
 
  0.682
ADAM19
Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity); ADAM metallopeptidase domain containing (918 aa)
           
  0.677
ELMOD1
ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (334 aa)
       
      0.644
SOX30
Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes (753 aa)
           
  0.613
UBLCP1
Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome; CTD family phosphatases (318 aa)
           
  0.612
ATP10B
Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily (1461 aa)
     
   
  0.588
TTC1
Tetratricopeptide repeat domain containing (292 aa)
     
   
  0.584
SLU7
Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation; Spliceosomal C complex (586 aa)
     
   
  0.582
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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