• Version:
  • 11.0 [archived version]
STRINGSTRING
SNN SNN ZNF131 ZNF131 TMEM14B TMEM14B CNEP1R1 CNEP1R1 TEX261 TEX261 PCDHB6 PCDHB6 LOC728763 LOC728763 TTC16 TTC16 BPIFB3 BPIFB3 KLHL5 KLHL5 LYPD6B LYPD6B
"PCDHB6" - Protocadherin beta-6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDHB6Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (794 aa)    
Predicted Functional Partners:
TTC16
Tetratricopeptide repeat domain containing (873 aa)
       
 
  0.608
TEX261
Protein TEX261; Testis expressed 261 (196 aa)
           
  0.507
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1 (142 aa)
           
  0.477
TMEM14B
Transmembrane protein 14B (151 aa)
           
  0.444
LOC728763
Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family (1655 aa)
           
  0.440
KLHL5
Kelch-like protein 5; Kelch like family member 5; BTB domain containing (755 aa)
           
  0.427
ZNF131
Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling; BTB domain containing (589 aa)
       
 
  0.425
BPIFB3
BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing (476 aa)
           
  0.421
SNN
Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation (88 aa)
           
  0.412
LYPD6B
Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing (207 aa)
           
  0.412
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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