| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL2 | PCDHB5 | ENSP00000427562 | ENSP00000231134 | Abelson tyrosine-protein kinase 2; Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundli [...] | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.471 |
| CDCA7L | PCDHB5 | ENSP00000383986 | ENSP00000231134 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.525 |
| CDCA7L | S100A13 | ENSP00000383986 | ENSP00000357688 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity) | 0.418 |
| CDCA7L | SCN2B | ENSP00000383986 | ENSP00000278947 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity); Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family | 0.416 |
| CLDN6 | CLDN9 | ENSP00000380131 | ENSP00000398017 | Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.904 |
| CLDN6 | PCDHB5 | ENSP00000380131 | ENSP00000231134 | Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.601 |
| CLDN9 | CLDN6 | ENSP00000398017 | ENSP00000380131 | Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.904 |
| CLDN9 | PCDHB5 | ENSP00000398017 | ENSP00000231134 | Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.629 |
| EFEMP1 | PCDHB5 | ENSP00000378058 | ENSP00000231134 | EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth; Belongs to the fibulin family | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.427 |
| ISY1-RAB43 | ISY1 | ENSP00000411822 | ENSP00000273541 | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex | 0.904 |
| ISY1-RAB43 | PCDHB5 | ENSP00000411822 | ENSP00000231134 | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.449 |
| ISY1 | ISY1-RAB43 | ENSP00000273541 | ENSP00000411822 | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing | 0.904 |
| ISY1 | PCDHB5 | ENSP00000273541 | ENSP00000231134 | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.429 |
| PCDHB5 | ABL2 | ENSP00000231134 | ENSP00000427562 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Abelson tyrosine-protein kinase 2; Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundli [...] | 0.471 |
| PCDHB5 | CDCA7L | ENSP00000231134 | ENSP00000383986 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | 0.525 |
| PCDHB5 | CLDN6 | ENSP00000231134 | ENSP00000380131 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.601 |
| PCDHB5 | CLDN9 | ENSP00000231134 | ENSP00000398017 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.629 |
| PCDHB5 | EFEMP1 | ENSP00000231134 | ENSP00000378058 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth; Belongs to the fibulin family | 0.427 |
| PCDHB5 | ISY1 | ENSP00000231134 | ENSP00000273541 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex | 0.429 |
| PCDHB5 | ISY1-RAB43 | ENSP00000231134 | ENSP00000411822 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing | 0.449 |
