| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD37 | FAM21A | ENSP00000335147 | ENSP00000282633 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | 0.439 |
| ANKRD37 | OLFML3 | ENSP00000335147 | ENSP00000322273 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | 0.435 |
| ANKRD37 | PRSS16 | ENSP00000335147 | ENSP00000230582 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.619 |
| FAM21A | ANKRD37 | ENSP00000282633 | ENSP00000335147 | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.439 |
| FAM21A | OLFML3 | ENSP00000282633 | ENSP00000322273 | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | 0.442 |
| FAM21A | PRSS16 | ENSP00000282633 | ENSP00000230582 | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.534 |
| HIST1H2BJ | PGBD1 | ENSP00000476136 | ENSP00000259883 | Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | 0.560 |
| HIST1H2BJ | PRSS16 | ENSP00000476136 | ENSP00000230582 | Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.530 |
| OLFML3 | ANKRD37 | ENSP00000322273 | ENSP00000335147 | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.435 |
| OLFML3 | FAM21A | ENSP00000322273 | ENSP00000282633 | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | 0.442 |
| OLFML3 | PRSS16 | ENSP00000322273 | ENSP00000230582 | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.673 |
| PGBD1 | HIST1H2BJ | ENSP00000259883 | ENSP00000476136 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.560 |
| PGBD1 | PRSS16 | ENSP00000259883 | ENSP00000230582 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.585 |
| POM121L2 | PRSS16 | ENSP00000392726 | ENSP00000230582 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.558 |
| POM121L2 | ZNF184 | ENSP00000392726 | ENSP00000211936 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Zinc finger protein 184; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.578 |
| PREP | PRSS16 | ENSP00000358106 | ENSP00000230582 | Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.756 |
| PRSS16 | ANKRD37 | ENSP00000230582 | ENSP00000335147 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.619 |
| PRSS16 | FAM21A | ENSP00000230582 | ENSP00000282633 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] | 0.534 |
| PRSS16 | HIST1H2BJ | ENSP00000230582 | ENSP00000476136 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.530 |
| PRSS16 | OLFML3 | ENSP00000230582 | ENSP00000322273 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family | 0.673 |
