node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | GART | ENSP00000360268 | ENSP00000371253 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.623 |
ALDH18A1 | GOLT1B | ENSP00000360268 | ENSP00000229314 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.621 |
ALDH18A1 | UMPS | ENSP00000360268 | ENSP00000232607 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | Uridine 5’-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family | 0.475 |
ASUN | GOLT1B | ENSP00000261191 | ENSP00000229314 | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.761 |
GART | ALDH18A1 | ENSP00000371253 | ENSP00000360268 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.623 |
GART | GOLT1B | ENSP00000371253 | ENSP00000229314 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.706 |
GART | STRAP | ENSP00000371253 | ENSP00000392270 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...] | 0.645 |
GART | UMPS | ENSP00000371253 | ENSP00000232607 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Uridine 5’-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family | 0.896 |
GOLT1B | ALDH18A1 | ENSP00000229314 | ENSP00000360268 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine | 0.621 |
GOLT1B | ASUN | ENSP00000229314 | ENSP00000261191 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing | 0.761 |
GOLT1B | GART | ENSP00000229314 | ENSP00000371253 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.706 |
GOLT1B | PLEKHA6 | ENSP00000229314 | ENSP00000272203 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Pleckstrin homology domain containing A6 | 0.625 |
GOLT1B | SEC22B | ENSP00000229314 | ENSP00000463393 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family | 0.620 |
GOLT1B | SLC25A3 | ENSP00000229314 | ENSP00000228318 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP); Solute carriers | 0.674 |
GOLT1B | SNRPE | ENSP00000229314 | ENSP00000400591 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Small nuclear ribonucleoprotein E; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing. May indirectly play a role in hair development | 0.675 |
GOLT1B | STRAP | ENSP00000229314 | ENSP00000392270 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...] | 0.626 |
GOLT1B | UMPS | ENSP00000229314 | ENSP00000232607 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Uridine 5’-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family | 0.787 |
GOLT1B | USE1 | ENSP00000229314 | ENSP00000263897 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs | 0.663 |
PLEKHA6 | GOLT1B | ENSP00000272203 | ENSP00000229314 | Pleckstrin homology domain containing A6 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.625 |
SEC22B | GOLT1B | ENSP00000463393 | ENSP00000229314 | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.620 |