| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BBS9 | C12orf57 | ENSP00000242067 | ENSP00000229281 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | 0.641 |
| BBS9 | CYTL1 | ENSP00000242067 | ENSP00000303550 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Cytokine-like protein 1; Cytokine like 1 | 0.670 |
| BBS9 | PLAC8 | ENSP00000242067 | ENSP00000399700 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Placenta-specific gene 8 protein; Placenta specific 8 | 0.677 |
| BBS9 | SUPT20H | ENSP00000242067 | ENSP00000417510 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | SPT20 homolog, SAGA complex component | 0.634 |
| BBS9 | TBL1XR1 | ENSP00000242067 | ENSP00000405574 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation; Belongs to the WD repeat EBI family | 0.546 |
| C12orf57 | BBS9 | ENSP00000229281 | ENSP00000242067 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | 0.641 |
| C12orf57 | CYTL1 | ENSP00000229281 | ENSP00000303550 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Cytokine-like protein 1; Cytokine like 1 | 0.734 |
| C12orf57 | HLA-A | ENSP00000229281 | ENSP00000379873 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | HLA class I histocompatibility antigen, A-3 alpha chain; Involved in the presentation of foreign antigens to the immune system; C1-set domain containing | 0.669 |
| C12orf57 | HLA-B | ENSP00000229281 | ENSP00000399168 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | HLA class I histocompatibility antigen, B-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; C1-set domain containing | 0.794 |
| C12orf57 | PLAC8 | ENSP00000229281 | ENSP00000399700 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Placenta-specific gene 8 protein; Placenta specific 8 | 0.737 |
| C12orf57 | PLXNB2 | ENSP00000229281 | ENSP00000409171 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | 0.806 |
| C12orf57 | SUPT20H | ENSP00000229281 | ENSP00000417510 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | SPT20 homolog, SAGA complex component | 0.730 |
| C12orf57 | TACC1 | ENSP00000229281 | ENSP00000321703 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues | 0.820 |
| C12orf57 | TAPBP | ENSP00000229281 | ENSP00000404833 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading); C1-set domain containing | 0.646 |
| C12orf57 | TBL1XR1 | ENSP00000229281 | ENSP00000405574 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation; Belongs to the WD repeat EBI family | 0.576 |
| CYTL1 | BBS9 | ENSP00000303550 | ENSP00000242067 | Cytokine-like protein 1; Cytokine like 1 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | 0.670 |
| CYTL1 | C12orf57 | ENSP00000303550 | ENSP00000229281 | Cytokine-like protein 1; Cytokine like 1 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family | 0.734 |
| CYTL1 | PLAC8 | ENSP00000303550 | ENSP00000399700 | Cytokine-like protein 1; Cytokine like 1 | Placenta-specific gene 8 protein; Placenta specific 8 | 0.736 |
| CYTL1 | SUPT20H | ENSP00000303550 | ENSP00000417510 | Cytokine-like protein 1; Cytokine like 1 | SPT20 homolog, SAGA complex component | 0.669 |
| CYTL1 | TBL1XR1 | ENSP00000303550 | ENSP00000405574 | Cytokine-like protein 1; Cytokine like 1 | F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation; Belongs to the WD repeat EBI family | 0.558 |
