RERGL protein (human) - STRING database

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RERGL

Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family (205 aa)

Predicted Functional Partners:

C10orf53

0.649

PIK3C2G

0.626

NKIRAS2

0.560

DIRAS1

0.544

IQSEC3

0.526

WSCD2

0.503

ZNF568

0.465

RASL10A

0.438

KIAA1467

0.433

RASEF

0.430

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf53	RERGL	ENSP00000363226	ENSP00000229002	Chromosome 10 open reading frame 53	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.649
DIRAS1	RERGL	ENSP00000325836	ENSP00000229002	GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.544
IQSEC3	KIAA1467	ENSP00000437554	ENSP00000197268	IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1	Protein FAM234B; KIAA1467	0.445
IQSEC3	RERGL	ENSP00000437554	ENSP00000229002	IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.526
KIAA1467	IQSEC3	ENSP00000197268	ENSP00000437554	Protein FAM234B; KIAA1467	IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1	0.445
KIAA1467	RERGL	ENSP00000197268	ENSP00000229002	Protein FAM234B; KIAA1467	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.433
NKIRAS2	RERGL	ENSP00000303580	ENSP00000229002	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.560
PIK3C2G	RERGL	ENSP00000445381	ENSP00000229002	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity); Belongs to the PI3/PI4-kinase family	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.626
RASEF	RERGL	ENSP00000365630	ENSP00000229002	Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.430
RASL10A	RERGL	ENSP00000216101	ENSP00000229002	Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	0.438
RERGL	C10orf53	ENSP00000229002	ENSP00000363226	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Chromosome 10 open reading frame 53	0.649
RERGL	DIRAS1	ENSP00000229002	ENSP00000325836	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family	0.544
RERGL	IQSEC3	ENSP00000229002	ENSP00000437554	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1	0.526
RERGL	KIAA1467	ENSP00000229002	ENSP00000197268	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Protein FAM234B; KIAA1467	0.433
RERGL	NKIRAS2	ENSP00000229002	ENSP00000303580	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily	0.560
RERGL	PIK3C2G	ENSP00000229002	ENSP00000445381	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity); Belongs to the PI3/PI4-kinase family	0.626
RERGL	RASEF	ENSP00000229002	ENSP00000365630	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing	0.430
RERGL	RASL10A	ENSP00000229002	ENSP00000216101	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family	0.438
RERGL	WSCD2	ENSP00000229002	ENSP00000331933	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	WSC domain containing 2; Belongs to the WSCD family	0.503
RERGL	ZNF568	ENSP00000229002	ENSP00000481819	Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family	Zinc finger protein 568; Has transcriptional repression activity, partially through the recuitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance pr [...]	0.465

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