PARP11 protein (human) - STRING database

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PARP11

Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases (338 aa)

Predicted Functional Partners:

RNF114

0.831

RNF166

0.787

CRLF3

0.707

KIAA2013

0.697

PPP1R26

0.693

PARP16

0.692

OTUD4

0.675

GM2A

0.674

RCC2

0.653

PARP8

0.642

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRLF3	GM2A	ENSP00000318804	ENSP00000349687	Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression; Fibronectin type III domain containing	Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3	0.677
CRLF3	PARP11	ENSP00000318804	ENSP00000228820	Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression; Fibronectin type III domain containing	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	0.707
GM2A	CRLF3	ENSP00000349687	ENSP00000318804	Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3	Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression; Fibronectin type III domain containing	0.677
GM2A	PARP11	ENSP00000349687	ENSP00000228820	Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	0.674
KIAA2013	OTUD4	ENSP00000365756	ENSP00000409279	Uncharacterized protein KIAA2013; KIAA2013	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	0.701
KIAA2013	PARP11	ENSP00000365756	ENSP00000228820	Uncharacterized protein KIAA2013; KIAA2013	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	0.697
KIAA2013	PPP1R26	ENSP00000365756	ENSP00000349274	Uncharacterized protein KIAA2013; KIAA2013	Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.457
KIAA2013	RCC2	ENSP00000365756	ENSP00000364585	Uncharacterized protein KIAA2013; KIAA2013	Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1	0.696
OTUD4	KIAA2013	ENSP00000409279	ENSP00000365756	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	Uncharacterized protein KIAA2013; KIAA2013	0.701
OTUD4	PARP11	ENSP00000409279	ENSP00000228820	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	0.675
OTUD4	PPP1R26	ENSP00000409279	ENSP00000349274	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.430
OTUD4	RCC2	ENSP00000409279	ENSP00000364585	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1	0.667
PARP11	CRLF3	ENSP00000228820	ENSP00000318804	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression; Fibronectin type III domain containing	0.707
PARP11	GM2A	ENSP00000228820	ENSP00000349687	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3	0.674
PARP11	KIAA2013	ENSP00000228820	ENSP00000365756	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Uncharacterized protein KIAA2013; KIAA2013	0.697
PARP11	OTUD4	ENSP00000228820	ENSP00000409279	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing	0.675
PARP11	PARP16	ENSP00000228820	ENSP00000261888	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Mono [ADP-ribose] polymerase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono- ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP- ribosyltransferases; Poly(ADP-ribose) polymerases	0.692
PARP11	PARP8	ENSP00000228820	ENSP00000281631	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	poly(ADP-ribose) polymerase family member 8	0.642
PARP11	PPP1R26	ENSP00000228820	ENSP00000349274	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.693
PARP11	RCC2	ENSP00000228820	ENSP00000364585	Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases	Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1	0.653

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