• Version:
  • 11.0 [archived version]
STRINGSTRING
SLC25A10 SLC25A10 STS STS PRNP PRNP PRR4 PRR4 CST4 CST4 ZG16B ZG16B LCN1 LCN1 PROL1 PROL1 PIP PIP LACRT LACRT SCGB2A1 SCGB2A1
"PRR4" - Proline-rich protein 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PRR4Proline-rich protein 4; Proline rich 4 (134 aa)    
Predicted Functional Partners:
LACRT
Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells (138 aa)
           
  0.691
LCN1
Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family (176 aa)
           
  0.669
STS
Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases (583 aa)
           
  0.627
PIP
Prolactin induced protein; Belongs to the PIP family (146 aa)
           
  0.560
SCGB2A1
Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; Belongs to the secretoglobin family. Lipophilin subfamily (95 aa)
           
  0.556
PROL1
Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection; Belongs to the PROL1/PROL3 family (248 aa)
           
  0.536
ZG16B
Zymogen granule protein 16B; Belongs to the jacalin lectin family (208 aa)
           
  0.536
SLC25A10
Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family (406 aa)
       
      0.519
PRNP
Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degr [...] (253 aa)
           
  0.514
CST4
Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 (141 aa)
           
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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