node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CST4 | LCN1 | ENSP00000217423 | ENSP00000263598 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.655 |
CST4 | PIP | ENSP00000217423 | ENSP00000291009 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 | Prolactin induced protein; Belongs to the PIP family | 0.570 |
CST4 | PRR4 | ENSP00000217423 | ENSP00000228811 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 | Proline-rich protein 4; Proline rich 4 | 0.473 |
LACRT | LCN1 | ENSP00000257867 | ENSP00000263598 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.700 |
LACRT | PIP | ENSP00000257867 | ENSP00000291009 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Prolactin induced protein; Belongs to the PIP family | 0.536 |
LACRT | PROL1 | ENSP00000257867 | ENSP00000382485 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection; Belongs to the PROL1/PROL3 family | 0.493 |
LACRT | PRR4 | ENSP00000257867 | ENSP00000228811 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Proline-rich protein 4; Proline rich 4 | 0.691 |
LACRT | SCGB2A1 | ENSP00000257867 | ENSP00000244930 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; Belongs to the secretoglobin family. Lipophilin subfamily | 0.441 |
LACRT | ZG16B | ENSP00000257867 | ENSP00000371715 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | Zymogen granule protein 16B; Belongs to the jacalin lectin family | 0.400 |
LCN1 | CST4 | ENSP00000263598 | ENSP00000217423 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 | 0.655 |
LCN1 | LACRT | ENSP00000263598 | ENSP00000257867 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | 0.700 |
LCN1 | PIP | ENSP00000263598 | ENSP00000291009 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Prolactin induced protein; Belongs to the PIP family | 0.673 |
LCN1 | PRR4 | ENSP00000263598 | ENSP00000228811 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Proline-rich protein 4; Proline rich 4 | 0.669 |
LCN1 | SCGB2A1 | ENSP00000263598 | ENSP00000244930 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; Belongs to the secretoglobin family. Lipophilin subfamily | 0.511 |
LCN1 | ZG16B | ENSP00000263598 | ENSP00000371715 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Zymogen granule protein 16B; Belongs to the jacalin lectin family | 0.416 |
PIP | CST4 | ENSP00000291009 | ENSP00000217423 | Prolactin induced protein; Belongs to the PIP family | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively; Cystatins, type 2 | 0.570 |
PIP | LACRT | ENSP00000291009 | ENSP00000257867 | Prolactin induced protein; Belongs to the PIP family | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells | 0.536 |
PIP | LCN1 | ENSP00000291009 | ENSP00000263598 | Prolactin induced protein; Belongs to the PIP family | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.673 |
PIP | PRR4 | ENSP00000291009 | ENSP00000228811 | Prolactin induced protein; Belongs to the PIP family | Proline-rich protein 4; Proline rich 4 | 0.560 |
PIP | SCGB2A1 | ENSP00000291009 | ENSP00000244930 | Prolactin induced protein; Belongs to the PIP family | Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; Belongs to the secretoglobin family. Lipophilin subfamily | 0.473 |