node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACBD3 | PPM1H | ENSP00000355777 | ENSP00000228705 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.613 |
ACBD3 | TMEM55B | ENSP00000355777 | ENSP00000381102 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate | 0.569 |
C2orf61 | PPM1H | ENSP00000408527 | ENSP00000228705 | Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5- methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.525 |
OR10G6 | PPM1H | ENSP00000477445 | ENSP00000228705 | Olfactory receptor 10G6; Odorant receptor; Olfactory receptors, family 10 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.618 |
OR10G6 | UBXN10 | ENSP00000477445 | ENSP00000364240 | Olfactory receptor 10G6; Odorant receptor; Olfactory receptors, family 10 | UBX domain-containing protein 10; VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 | 0.801 |
PDP2 | PPM1E | ENSP00000309548 | ENSP00000312411 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | 0.421 |
PDP2 | PPM1H | ENSP00000309548 | ENSP00000228705 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.721 |
PDP2 | PPM1K | ENSP00000309548 | ENSP00000477341 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | 0.406 |
PDP2 | PPTC7 | ENSP00000309548 | ENSP00000346255 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | PTC7 protein phosphatase homolog | 0.616 |
PPM1D | PPM1H | ENSP00000306682 | ENSP00000228705 | Protein phosphatase 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.542 |
PPM1D | PPTC7 | ENSP00000306682 | ENSP00000346255 | Protein phosphatase 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation | PTC7 protein phosphatase homolog | 0.537 |
PPM1E | PDP2 | ENSP00000312411 | ENSP00000309548 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | 0.421 |
PPM1E | PPM1H | ENSP00000312411 | ENSP00000228705 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | 0.525 |
PPM1E | PPTC7 | ENSP00000312411 | ENSP00000346255 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | PTC7 protein phosphatase homolog | 0.581 |
PPM1H | ACBD3 | ENSP00000228705 | ENSP00000355777 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins | 0.613 |
PPM1H | C2orf61 | ENSP00000228705 | ENSP00000408527 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5- methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) | 0.525 |
PPM1H | OR10G6 | ENSP00000228705 | ENSP00000477445 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | Olfactory receptor 10G6; Odorant receptor; Olfactory receptors, family 10 | 0.618 |
PPM1H | PDP2 | ENSP00000228705 | ENSP00000309548 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Protein phosphatases, Mg2+/Mn2+ dependent | 0.721 |
PPM1H | PPM1D | ENSP00000228705 | ENSP00000306682 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | Protein phosphatase 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation | 0.542 |
PPM1H | PPM1E | ENSP00000228705 | ENSP00000312411 | Protein phosphatase 1H; Dephosphorylates CDKN1B at ’Thr-187’, thus removing a signal for proteasomal degradation; Belongs to the PP2C family | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | 0.525 |