node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf58 | C5orf63 | ENSP00000228136 | ENSP00000454153 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 | 0.536 |
C11orf58 | CHP1 | ENSP00000228136 | ENSP00000335632 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | 0.475 |
C11orf58 | DPH3 | ENSP00000228136 | ENSP00000419599 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) | 0.536 |
C11orf58 | DPH5 | ENSP00000228136 | ENSP00000359127 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | 0.516 |
C11orf58 | NAP1L1 | ENSP00000228136 | ENSP00000477538 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation; Belongs to the nucleosome assembly protein (NAP) family | 0.492 |
C11orf58 | PSMB7 | ENSP00000228136 | ENSP00000259457 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | 0.493 |
C11orf58 | PTMA | ENSP00000228136 | ENSP00000344547 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Prothymosin alpha; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections | 0.700 |
C11orf58 | RBP7 | ENSP00000228136 | ENSP00000294435 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Retinoid-binding protein 7; Intracellular transport of retinol; Fatty acid binding protein family | 0.485 |
C11orf58 | SCG5 | ENSP00000228136 | ENSP00000300175 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins | 0.497 |
C11orf58 | SHFM1 | ENSP00000228136 | ENSP00000481021 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | Putative protein SEM1, isoform 2; Split hand/foot malformation (ectrodactyly) type 1 | 0.478 |
C5orf63 | C11orf58 | ENSP00000454153 | ENSP00000228136 | Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.536 |
CHP1 | C11orf58 | ENSP00000335632 | ENSP00000228136 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.475 |
DPH3 | C11orf58 | ENSP00000419599 | ENSP00000228136 | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.536 |
DPH3 | DPH5 | ENSP00000419599 | ENSP00000359127 | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | 0.923 |
DPH5 | C11orf58 | ENSP00000359127 | ENSP00000228136 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.516 |
DPH5 | DPH3 | ENSP00000359127 | ENSP00000419599 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) | 0.923 |
NAP1L1 | C11orf58 | ENSP00000477538 | ENSP00000228136 | Nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation; Belongs to the nucleosome assembly protein (NAP) family | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.492 |
PSMB7 | C11orf58 | ENSP00000259457 | ENSP00000228136 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.493 |
PSMB7 | SHFM1 | ENSP00000259457 | ENSP00000481021 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | Putative protein SEM1, isoform 2; Split hand/foot malformation (ectrodactyly) type 1 | 0.903 |
PTMA | C11orf58 | ENSP00000344547 | ENSP00000228136 | Prothymosin alpha; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family | 0.700 |