• Version:
  • 11.0 [archived version]
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RBP7 RBP7 DPH5 DPH5 C5orf63 C5orf63 DPH3 DPH3 NAP1L1 NAP1L1 C11orf58 C11orf58 SHFM1 SHFM1 PSMB7 PSMB7 PTMA PTMA CHP1 CHP1 SCG5 SCG5
"C11orf58" - Small acidic protein in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C11orf58Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family (183 aa)    
Predicted Functional Partners:
PTMA
Prothymosin alpha; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections (111 aa)
     
 
  0.700
DPH3
DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) (82 aa)
           
  0.536
C5orf63
Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 (138 aa)
           
  0.536
DPH5
Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis (285 aa)
     
   
  0.516
SCG5
Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins (212 aa)
           
  0.497
PSMB7
Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] (277 aa)
     
 
  0.493
NAP1L1
Nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation; Belongs to the nucleosome assembly protein (NAP) family (391 aa)
     
      0.492
RBP7
Retinoid-binding protein 7; Intracellular transport of retinol; Fatty acid binding protein family (134 aa)
           
  0.485
SHFM1
Putative protein SEM1, isoform 2; Split hand/foot malformation (ectrodactyly) type 1 (118 aa)
           
  0.478
CHP1
Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] (195 aa)
           
  0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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