| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC13 | SPRYD3 | ENSP00000421842 | ENSP00000301463 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | SPRY domain containing 3 | 0.720 |
| ANAPC13 | TMEM109 | ENSP00000421842 | ENSP00000227525 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.541 |
| C17orf62 | TAPBPL | ENSP00000388909 | ENSP00000266556 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression; C1-set domain containing | 0.525 |
| C17orf62 | TMEM109 | ENSP00000388909 | ENSP00000227525 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.529 |
| C17orf62 | TMEM199 | ENSP00000388909 | ENSP00000292114 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.730 |
| C17orf62 | TMEM41A | ENSP00000388909 | ENSP00000406885 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 41A; Belongs to the TMEM41 family | 0.715 |
| CCDC115 | TMEM109 | ENSP00000259229 | ENSP00000227525 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.529 |
| CCDC115 | TMEM199 | ENSP00000259229 | ENSP00000292114 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.996 |
| FAM184B | MAB21L3 | ENSP00000265018 | ENSP00000358512 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | Protein mab-21-like 3; Mab-21 like 3 | 0.663 |
| FAM184B | TMEM109 | ENSP00000265018 | ENSP00000227525 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.568 |
| MAB21L3 | FAM184B | ENSP00000358512 | ENSP00000265018 | Protein mab-21-like 3; Mab-21 like 3 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | 0.663 |
| MAB21L3 | TMEM109 | ENSP00000358512 | ENSP00000227525 | Protein mab-21-like 3; Mab-21 like 3 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.604 |
| SPRYD3 | ANAPC13 | ENSP00000301463 | ENSP00000421842 | SPRY domain containing 3 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.720 |
| SPRYD3 | TMEM109 | ENSP00000301463 | ENSP00000227525 | SPRY domain containing 3 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.547 |
| TAPBPL | C17orf62 | ENSP00000266556 | ENSP00000388909 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression; C1-set domain containing | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.525 |
| TAPBPL | TMEM109 | ENSP00000266556 | ENSP00000227525 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression; C1-set domain containing | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.533 |
| TAPBPL | TMEM199 | ENSP00000266556 | ENSP00000292114 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression; C1-set domain containing | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.542 |
| TAPBPL | TMEM41A | ENSP00000266556 | ENSP00000406885 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression; C1-set domain containing | Transmembrane protein 41A; Belongs to the TMEM41 family | 0.605 |
| TMEM109 | ANAPC13 | ENSP00000227525 | ENSP00000421842 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.541 |
| TMEM109 | C17orf62 | ENSP00000227525 | ENSP00000388909 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.529 |
