FRG1 protein (human) - STRING database

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FRG1

Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family (258 aa)

Predicted Functional Partners:

FRG2

0.902

DUX4

0.798

MTMR1

0.776

DUX4L7

0.774

CWC22

0.767

DUX4L8

0.757

DUX4L1

0.755

TNNT3

0.645

PRPF19

0.613

FAM71B

0.609

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CWC22	FRG1	ENSP00000387006	ENSP00000226798	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	0.767
CWC22	PRPF19	ENSP00000387006	ENSP00000227524	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	0.997
DUX4	DUX4L1	ENSP00000458065	ENSP00000451207	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.800
DUX4	DUX4L7	ENSP00000458065	ENSP00000451411	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.801
DUX4	DUX4L8	ENSP00000458065	ENSP00000485452	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.801
DUX4	FRG1	ENSP00000458065	ENSP00000226798	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	0.798
DUX4	FRG2	ENSP00000458065	ENSP00000424015	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Protein FRG2; FSHD region gene 2	0.876
DUX4L1	DUX4	ENSP00000451207	ENSP00000458065	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.800
DUX4L1	DUX4L7	ENSP00000451207	ENSP00000451411	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.808
DUX4L1	DUX4L8	ENSP00000451207	ENSP00000485452	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.815
DUX4L1	FRG1	ENSP00000451207	ENSP00000226798	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	0.755
DUX4L1	FRG2	ENSP00000451207	ENSP00000424015	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Protein FRG2; FSHD region gene 2	0.861
DUX4L7	DUX4	ENSP00000451411	ENSP00000458065	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.801
DUX4L7	DUX4L1	ENSP00000451411	ENSP00000451207	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.808
DUX4L7	DUX4L8	ENSP00000451411	ENSP00000485452	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.814
DUX4L7	FRG1	ENSP00000451411	ENSP00000226798	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B; Belongs to the FRG1 family	0.774
DUX4L7	FRG2	ENSP00000451411	ENSP00000424015	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Protein FRG2; FSHD region gene 2	0.848
DUX4L8	DUX4	ENSP00000485452	ENSP00000458065	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.801
DUX4L8	DUX4L1	ENSP00000485452	ENSP00000451207	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.815
DUX4L8	DUX4L7	ENSP00000485452	ENSP00000451411	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.814

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