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STRINGSTRING
ENGASE ENGASE GNS GNS HGSNAT HGSNAT SGSH SGSH ARSH ARSH IDUA IDUA HSD17B1 HSD17B1 NAGLU NAGLU TMED4 TMED4 TMED9 TMED9 TMED10 TMED10
"NAGLU" - Alpha-N-acetylglucosaminidase in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NAGLUAlpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate (743 aa)    
Predicted Functional Partners:
HGSNAT
Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase (635 aa)
      
 
  0.990
TMED9
Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of [...] (235 aa)
      
      0.976
TMED4
Transmembrane emp24 domain-containing protein 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity); Transmembrane p24 trafficking proteins (227 aa)
        
      0.976
TMED10
Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] (219 aa)
        
      0.976
SGSH
N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation; Belongs to the sulfatase family (502 aa)
      
   
  0.910
HSD17B1
Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH; Short chain dehydrogenase/reductase superfamily (328 aa)
            
  0.763
GNS
N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family (552 aa)
      
   
  0.760
IDUA
Alpha-L-iduronidase; Iduronidase, alpha-L- (653 aa)
      
   
  0.752
ARSH
Arylsulfatase family member H; Sulfatases (562 aa)
      
   
  0.717
ENGASE
Cytosolic endo-beta-N-acetylglucosaminidase; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N’-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (743 aa)
      
   
  0.689
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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