• Version:
  • 11.0 [archived version]
STRINGSTRING
SYNPR SYNPR CMTM4 CMTM4 TMEM50B TMEM50B SYP SYP SYNGR2 SYNGR2 ENSG00000250151 ENSG00000250151 CANX CANX TMC6 TMC6 SCARA3 SCARA3 TMC8 TMC8 TK1 TK1
"SYNGR2" - Synaptogyrin-2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
SYNGR2Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane; Belongs to the synaptogyrin family (224 aa)    
Predicted Functional Partners:
TMC6
Transmembrane channel-like protein 6; Probable ion channel; Transmembrane channel likes (805 aa)
     
   
  0.906
TMC8
Transmembrane channel-like protein 8; Probable ion channel; Transmembrane channel likes (726 aa)
     
   
  0.904
SYNPR
Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family (285 aa)
     
 
  0.760
TK1
Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family (234 aa)
     
   
  0.654
CMTM4
CKLF like MARVEL transmembrane domain containing 4 (234 aa)
           
  0.633
CANX
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] (592 aa)
           
  0.629
SYP
Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity); Synaptophysins (313 aa)
     
 
  0.531
TMEM50B
Transmembrane protein 50B (158 aa)
           
  0.531
ENSG00000250151
ARPC4-TTLL3 readthrough (625 aa)
           
  0.526
SCARA3
Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors (606 aa)
       
      0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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