DRG2 protein (human) - STRING database

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DRG2

Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family (364 aa)

Predicted Functional Partners:

RWDD1

0.992

ZC3H15

0.959

GCN1L1

0.901

RWDD4

0.874

ZCCHC4

0.757

EAPP

0.712

RPS4X

0.693

RPL3

0.674

RPS11

0.666

RPL9

0.659

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DRG2	EAPP	ENSP00000225729	ENSP00000250454	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	0.712
DRG2	GCN1L1	ENSP00000225729	ENSP00000300648	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	0.901
DRG2	RPL3	ENSP00000225729	ENSP00000346001	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins	0.674
DRG2	RPL9	ENSP00000225729	ENSP00000400467	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	L ribosomal proteins	0.659
DRG2	RPS11	ENSP00000225729	ENSP00000270625	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family	0.666
DRG2	RPS4X	ENSP00000225729	ENSP00000362744	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	Ribosomal protein S4, X-linked; Belongs to the eukaryotic ribosomal protein eS4 family	0.693
DRG2	RWDD1	ENSP00000225729	ENSP00000420357	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family	0.992
DRG2	RWDD4	ENSP00000225729	ENSP00000388920	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	RWD domain containing 4	0.874
DRG2	ZC3H15	ENSP00000225729	ENSP00000338788	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type	0.959
DRG2	ZCCHC4	ENSP00000225729	ENSP00000303468	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	Zinc finger CCHC domain-containing protein 4; May be a methyltransferase; Seven-beta-strand methyltransferase motif containing	0.757
EAPP	DRG2	ENSP00000250454	ENSP00000225729	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	0.712
EAPP	ZCCHC4	ENSP00000250454	ENSP00000303468	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	Zinc finger CCHC domain-containing protein 4; May be a methyltransferase; Seven-beta-strand methyltransferase motif containing	0.630
GCN1L1	DRG2	ENSP00000300648	ENSP00000225729	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	0.901
GCN1L1	RWDD1	ENSP00000300648	ENSP00000420357	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family	0.850
GCN1L1	RWDD4	ENSP00000300648	ENSP00000388920	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	RWD domain containing 4	0.499
GCN1L1	ZC3H15	ENSP00000300648	ENSP00000338788	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type	0.431
RPL3	DRG2	ENSP00000346001	ENSP00000225729	60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins	Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family	0.674
RPL3	RPL9	ENSP00000346001	ENSP00000400467	60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins	L ribosomal proteins	0.999
RPL3	RPS11	ENSP00000346001	ENSP00000270625	60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family	0.999
RPL3	RPS4X	ENSP00000346001	ENSP00000362744	60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins	Ribosomal protein S4, X-linked; Belongs to the eukaryotic ribosomal protein eS4 family	0.999

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