node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QL4 | CCDC47 | ENSP00000335285 | ENSP00000225726 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Coiled-coil domain containing 47 | 0.641 |
CCDC47 | C1QL4 | ENSP00000225726 | ENSP00000335285 | Coiled-coil domain containing 47 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.641 |
CCDC47 | CLMP | ENSP00000225726 | ENSP00000405577 | Coiled-coil domain containing 47 | CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development; I-set domain containing | 0.578 |
CCDC47 | IRAK1 | ENSP00000225726 | ENSP00000358997 | Coiled-coil domain containing 47 | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | 0.725 |
CCDC47 | KIAA1211L | ENSP00000225726 | ENSP00000380996 | Coiled-coil domain containing 47 | Uncharacterized protein KIAA1211-like; KIAA1211 like | 0.740 |
CCDC47 | MAN1A2 | ENSP00000225726 | ENSP00000348959 | Coiled-coil domain containing 47 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | 0.631 |
CCDC47 | SARM1 | ENSP00000225726 | ENSP00000468032 | Coiled-coil domain containing 47 | Sterile alpha and TIR motif-containing protein 1; Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent ac [...] | 0.789 |
CCDC47 | SCYL1 | ENSP00000225726 | ENSP00000270176 | Coiled-coil domain containing 47 | N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro | 0.743 |
CCDC47 | STRN3 | ENSP00000225726 | ENSP00000350071 | Coiled-coil domain containing 47 | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Protein phosphatase 2 regulatory subunits | 0.530 |
CCDC47 | TCP11L1 | ENSP00000225726 | ENSP00000335595 | Coiled-coil domain containing 47 | T-complex protein 11-like protein 1; T-complex 11 like 1 | 0.750 |
CCDC47 | TMEM173 | ENSP00000225726 | ENSP00000331288 | Coiled-coil domain containing 47 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition [...] | 0.530 |
CLMP | CCDC47 | ENSP00000405577 | ENSP00000225726 | CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development; I-set domain containing | Coiled-coil domain containing 47 | 0.578 |
IRAK1 | CCDC47 | ENSP00000358997 | ENSP00000225726 | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | Coiled-coil domain containing 47 | 0.725 |
IRAK1 | SARM1 | ENSP00000358997 | ENSP00000468032 | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | Sterile alpha and TIR motif-containing protein 1; Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent ac [...] | 0.827 |
IRAK1 | TMEM173 | ENSP00000358997 | ENSP00000331288 | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition [...] | 0.583 |
KIAA1211L | CCDC47 | ENSP00000380996 | ENSP00000225726 | Uncharacterized protein KIAA1211-like; KIAA1211 like | Coiled-coil domain containing 47 | 0.740 |
KIAA1211L | MAN1A2 | ENSP00000380996 | ENSP00000348959 | Uncharacterized protein KIAA1211-like; KIAA1211 like | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | 0.630 |
KIAA1211L | STRN3 | ENSP00000380996 | ENSP00000350071 | Uncharacterized protein KIAA1211-like; KIAA1211 like | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Protein phosphatase 2 regulatory subunits | 0.525 |
KIAA1211L | TCP11L1 | ENSP00000380996 | ENSP00000335595 | Uncharacterized protein KIAA1211-like; KIAA1211 like | T-complex protein 11-like protein 1; T-complex 11 like 1 | 0.750 |
MAN1A2 | CCDC47 | ENSP00000348959 | ENSP00000225726 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | Coiled-coil domain containing 47 | 0.631 |