| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPA | SHPK | ENSP00000263080 | ENSP00000225519 | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.796 |
| ASPA | SPATA22 | ENSP00000263080 | ENSP00000459580 | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.548 |
| CRISP2 | SHPK | ENSP00000339155 | ENSP00000225519 | Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.630 |
| CRISP2 | SPATA22 | ENSP00000339155 | ENSP00000459580 | Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.400 |
| CTNS | ENSG00000196689 | ENSP00000371294 | ENSP00000459962 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | Transient receptor potential cation channel, subfamily V, member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibit [...] | 0.640 |
| CTNS | FGGY | ENSP00000371294 | ENSP00000360262 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family | 0.718 |
| CTNS | SHPK | ENSP00000371294 | ENSP00000225519 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.906 |
| CTNS | VR1 | ENSP00000371294 | ENSP00000461007 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.640 |
| ENSG00000196689 | CTNS | ENSP00000459962 | ENSP00000371294 | Transient receptor potential cation channel, subfamily V, member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibit [...] | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | 0.640 |
| ENSG00000196689 | SHPK | ENSP00000459962 | ENSP00000225519 | Transient receptor potential cation channel, subfamily V, member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibit [...] | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.551 |
| FAM126A | SHPK | ENSP00000403396 | ENSP00000225519 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway (Probable) | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.817 |
| FGGY | CTNS | ENSP00000360262 | ENSP00000371294 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | 0.718 |
| FGGY | PSMD3 | ENSP00000360262 | ENSP00000264639 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family | 26S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S3 family | 0.545 |
| FGGY | SHPK | ENSP00000360262 | ENSP00000225519 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.759 |
| MSH4 | SHPK | ENSP00000263187 | ENSP00000225519 | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.600 |
| MSH4 | SPATA22 | ENSP00000263187 | ENSP00000459580 | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.500 |
| PSMD3 | FGGY | ENSP00000264639 | ENSP00000360262 | 26S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S3 family | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family | 0.545 |
| PSMD3 | SHPK | ENSP00000264639 | ENSP00000225519 | 26S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S3 family | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | 0.548 |
| SHPK | ASPA | ENSP00000225519 | ENSP00000263080 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.796 |
| SHPK | CRISP2 | ENSP00000225519 | ENSP00000339155 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism | Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family | 0.630 |
