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  • 11.0 [archived version]
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ABCF1 ABCF1 LARP4B LARP4B RPL8 RPL8 RPS29 RPS29 ATXN2L ATXN2L NUFIP2 NUFIP2 DDX6 DDX6 G3BP2 G3BP2 G3BP1 G3BP1 FMR1 FMR1 NUFIP1 NUFIP1
"NUFIP2" - Nuclear fragile X mental retardation-interacting protein 2 in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NUFIP2Nuclear fragile X mental retardation-interacting protein 2; Binds RNA (695 aa)    
Predicted Functional Partners:
FMR1
Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsyna [...] (632 aa)
     
 
  0.932
ATXN2L
Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation; Belongs to the ataxin-2 family (1097 aa)
     
 
  0.904
G3BP1
Ras GTPase-activating protein-binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5’ to [...] (466 aa)
     
 
  0.849
G3BP2
Ras GTPase-activating protein-binding protein 2; Probable scaffold protein that may be involved in mRNA transport; RNA binding motif containing (482 aa)
     
      0.827
DDX6
Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily (483 aa)
     
 
  0.795
NUFIP1
Nuclear fragile X mental retardation-interacting protein 1; Binds RNA (495 aa)
           
  0.781
ABCF1
ATP-binding cassette sub-family F member 1; Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis; ATP binding cassette subfamily F (845 aa)
     
 
  0.771
RPL8
60S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
     
 
  0.766
LARP4B
La-related protein 4B; Stimulates mRNA translation; La ribonucleoprotein domain containing (738 aa)
     
 
    0.738
RPS29
Ribosomal protein S29 (67 aa)
     
 
    0.733
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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