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STRINGSTRING
CRYBA1 CRYBA1 BFSP2 BFSP2 CRYAB CRYAB GJA8 GJA8 CRYA1 CRYA1 BFSP1 BFSP1 HSPB4 HSPB4 LIM2 LIM2 CRYBB1 CRYBB1 GJA3 GJA3 HSF4 HSF4
"CRYBA1" - Beta-crystallin A3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurence
Coexpression
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[Homology]
Score
CRYBA1Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens (215 aa)    
Predicted Functional Partners:
HSPB4
Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (173 aa)
      
 
  0.938
CRYA1
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (173 aa)
      
   
  0.905
CRYAB
Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (175 aa)
      
 
  0.873
GJA3
Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily (435 aa)
            
  0.818
BFSP2
Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family (415 aa)
      
   
  0.784
GJA8
Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (433 aa)
      
   
  0.775
LIM2
Lens intrinsic membrane protein 2 (215 aa)
      
   
  0.748
CRYBB1
Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family (252 aa)
    
 
0.721
HSF4
Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription (492 aa)
            
  0.709
BFSP1
Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family (665 aa)
      
   
  0.703
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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