node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HDHD2 | SKOR2 | ENSP00000300605 | ENSP00000483333 | Haloacid dehalogenase like hydrolase domain containing 2 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | 0.703 |
HDHD2 | TBC1D12 | ENSP00000300605 | ENSP00000225235 | Haloacid dehalogenase like hydrolase domain containing 2 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.682 |
LRRTM3 | PLCE1 | ENSP00000355187 | ENSP00000360431 | Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system; Belongs to the LRRTM family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | 0.500 |
LRRTM3 | TBC1D12 | ENSP00000355187 | ENSP00000225235 | Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system; Belongs to the LRRTM family | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.764 |
PDE6C | TBC1D12 | ENSP00000360502 | ENSP00000225235 | Cone cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP; Phosphodiesterases | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.690 |
PLCE1 | LRRTM3 | ENSP00000360431 | ENSP00000355187 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system; Belongs to the LRRTM family | 0.500 |
PLCE1 | TBC1D12 | ENSP00000360431 | ENSP00000225235 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.646 |
PLEKHS1 | TBC1D12 | ENSP00000358316 | ENSP00000225235 | Pleckstrin homology domain containing S1 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.593 |
SGSM2 | TBC1D12 | ENSP00000268989 | ENSP00000225235 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.624 |
SGSM2 | TBC1D23 | ENSP00000268989 | ENSP00000377700 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but inste [...] | 0.581 |
SGSM2 | TBC1D7 | ENSP00000268989 | ENSP00000475727 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...] | 0.608 |
SKOR2 | HDHD2 | ENSP00000483333 | ENSP00000300605 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | Haloacid dehalogenase like hydrolase domain containing 2 | 0.703 |
SKOR2 | TBC1D12 | ENSP00000483333 | ENSP00000225235 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 0.557 |
TBC1D12 | HDHD2 | ENSP00000225235 | ENSP00000300605 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | Haloacid dehalogenase like hydrolase domain containing 2 | 0.682 |
TBC1D12 | LRRTM3 | ENSP00000225235 | ENSP00000355187 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system; Belongs to the LRRTM family | 0.764 |
TBC1D12 | PDE6C | ENSP00000225235 | ENSP00000360502 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | Cone cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP; Phosphodiesterases | 0.690 |
TBC1D12 | PLCE1 | ENSP00000225235 | ENSP00000360431 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | 0.646 |
TBC1D12 | PLEKHS1 | ENSP00000225235 | ENSP00000358316 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | Pleckstrin homology domain containing S1 | 0.593 |
TBC1D12 | SGSM2 | ENSP00000225235 | ENSP00000268989 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | 0.624 |
TBC1D12 | SKOR2 | ENSP00000225235 | ENSP00000483333 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | 0.557 |