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  • 11.0 [archived version]
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DNAJC1 DNAJC1 TPD52L1 TPD52L1 DNAJC21 DNAJC21 DNAJC6 DNAJC6 DNAJC8 DNAJC8 DNAJC12 DNAJC12 NT5C3B NT5C3B DNAJC25 DNAJC25 DNAJC24 DNAJC24 DNAJB1 DNAJB1 DNAJC18 DNAJC18
"DNAJC12" - DnaJ heat shock protein family member C12 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DNAJC12DnaJ heat shock protein family member C12 (198 aa)    
Predicted Functional Partners:
DNAJC8
DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins (253 aa)
     
   
  0.740
DNAJC1
DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins (554 aa)
     
   
  0.731
DNAJC25
DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family (360 aa)
     
 
  0.729
TPD52L1
Tumor protein D52 like 1 (204 aa)
           
  0.682
DNAJB1
DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (340 aa)
   
 
  0.674
NT5C3B
7-methylguanosine phosphate-specific 5’-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (300 aa)
           
  0.659
DNAJC18
DnaJ heat shock protein family member C18 (358 aa)
   
 
  0.652
DNAJC21
DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins (576 aa)
   
 
  0.649
DNAJC6
Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing (970 aa)
     
 
  0.643
DNAJC24
DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family (149 aa)
   
 
  0.629
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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