node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJB1 | DNAJC12 | ENSP00000254322 | ENSP00000225171 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) | DnaJ heat shock protein family member C12 | 0.674 |
DNAJB1 | DNAJC24 | ENSP00000254322 | ENSP00000417548 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.530 |
DNAJB1 | DNAJC6 | ENSP00000254322 | ENSP00000360108 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) | Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing | 0.733 |
DNAJB1 | DNAJC8 | ENSP00000254322 | ENSP00000263697 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.500 |
DNAJC1 | DNAJC12 | ENSP00000366179 | ENSP00000225171 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | DnaJ heat shock protein family member C12 | 0.731 |
DNAJC1 | DNAJC21 | ENSP00000366179 | ENSP00000371451 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins | 0.498 |
DNAJC1 | DNAJC24 | ENSP00000366179 | ENSP00000417548 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.626 |
DNAJC1 | DNAJC6 | ENSP00000366179 | ENSP00000360108 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing | 0.678 |
DNAJC1 | DNAJC8 | ENSP00000366179 | ENSP00000263697 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.606 |
DNAJC12 | DNAJB1 | ENSP00000225171 | ENSP00000254322 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) | 0.674 |
DNAJC12 | DNAJC1 | ENSP00000225171 | ENSP00000366179 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins | 0.731 |
DNAJC12 | DNAJC18 | ENSP00000225171 | ENSP00000302843 | DnaJ heat shock protein family member C12 | DnaJ heat shock protein family member C18 | 0.652 |
DNAJC12 | DNAJC21 | ENSP00000225171 | ENSP00000371451 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins | 0.649 |
DNAJC12 | DNAJC24 | ENSP00000225171 | ENSP00000417548 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.629 |
DNAJC12 | DNAJC25 | ENSP00000225171 | ENSP00000320650 | DnaJ heat shock protein family member C12 | DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family | 0.729 |
DNAJC12 | DNAJC6 | ENSP00000225171 | ENSP00000360108 | DnaJ heat shock protein family member C12 | Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing | 0.643 |
DNAJC12 | DNAJC8 | ENSP00000225171 | ENSP00000263697 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.740 |
DNAJC12 | NT5C3B | ENSP00000225171 | ENSP00000389948 | DnaJ heat shock protein family member C12 | 7-methylguanosine phosphate-specific 5’-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates | 0.659 |
DNAJC12 | TPD52L1 | ENSP00000225171 | ENSP00000434142 | DnaJ heat shock protein family member C12 | Tumor protein D52 like 1 | 0.682 |
DNAJC18 | DNAJC12 | ENSP00000302843 | ENSP00000225171 | DnaJ heat shock protein family member C18 | DnaJ heat shock protein family member C12 | 0.652 |