| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAT1 | SFXN3 | ENSP00000265838 | ENSP00000224807 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.854 |
| ACAT1 | UQCRQ | ENSP00000265838 | ENSP00000367939 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Cytochrome b-c1 complex subunit 8; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone; Belongs to the UQCRQ/QCR8 family | 0.445 |
| CCAR2 | MAT2B | ENSP00000310670 | ENSP00000325425 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part o [...] | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine. Can bind NADP (in vitro); Short chain dehydrogenase/reductase superfamily | 0.667 |
| CCAR2 | SFXN3 | ENSP00000310670 | ENSP00000224807 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part o [...] | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.689 |
| CCAR2 | STOX1 | ENSP00000310670 | ENSP00000298596 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part o [...] | Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) | 0.663 |
| FAM3C | SFXN3 | ENSP00000353025 | ENSP00000224807 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.674 |
| LY6E | SFXN3 | ENSP00000428572 | ENSP00000224807 | Lymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response; LY6/PLAUR domain containing | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.799 |
| MAT2B | CCAR2 | ENSP00000325425 | ENSP00000310670 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine. Can bind NADP (in vitro); Short chain dehydrogenase/reductase superfamily | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part o [...] | 0.667 |
| MAT2B | SFXN3 | ENSP00000325425 | ENSP00000224807 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine. Can bind NADP (in vitro); Short chain dehydrogenase/reductase superfamily | Sideroflexin-3; Potential iron transporter; Sideroflexins | 0.661 |
| MAT2B | STOX1 | ENSP00000325425 | ENSP00000298596 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine. Can bind NADP (in vitro); Short chain dehydrogenase/reductase superfamily | Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) | 0.594 |
| SFXN3 | ACAT1 | ENSP00000224807 | ENSP00000265838 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.854 |
| SFXN3 | CCAR2 | ENSP00000224807 | ENSP00000310670 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part o [...] | 0.689 |
| SFXN3 | FAM3C | ENSP00000224807 | ENSP00000353025 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | 0.674 |
| SFXN3 | LY6E | ENSP00000224807 | ENSP00000428572 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Lymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response; LY6/PLAUR domain containing | 0.799 |
| SFXN3 | MAT2B | ENSP00000224807 | ENSP00000325425 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine. Can bind NADP (in vitro); Short chain dehydrogenase/reductase superfamily | 0.661 |
| SFXN3 | STOX1 | ENSP00000224807 | ENSP00000298596 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) | 0.689 |
| SFXN3 | STOX2 | ENSP00000224807 | ENSP00000311257 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Storkhead-box protein 2; Storkhead box 2 | 0.716 |
| SFXN3 | TIMM50 | ENSP00000224807 | ENSP00000445806 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body; Belongs to the TIM50 family | 0.771 |
| SFXN3 | TMEM51 | ENSP00000224807 | ENSP00000394899 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Transmembrane protein 51 | 0.738 |
| SFXN3 | UQCRQ | ENSP00000224807 | ENSP00000367939 | Sideroflexin-3; Potential iron transporter; Sideroflexins | Cytochrome b-c1 complex subunit 8; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone; Belongs to the UQCRQ/QCR8 family | 0.815 |
