RLN1 protein (human) - STRING database

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RLN1

Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family (185 aa)

Predicted Functional Partners:

RXFP1

0.977

RXFP2

0.952

RLN2

0.845

RLN3

0.811

INSL5

0.807

INSL3

0.758

INSL4

0.754

RXFP3

0.748

LGR6

0.710

RXFP4

0.708

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
INSL3	INSL4	ENSP00000369017	ENSP00000239316	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	0.745
INSL3	INSL5	ENSP00000369017	ENSP00000302724	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	0.792
INSL3	RLN1	ENSP00000369017	ENSP00000223862	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family	0.758
INSL3	RLN2	ENSP00000369017	ENSP00000371040	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands	0.965
INSL3	RLN3	ENSP00000369017	ENSP00000397415	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family	0.978
INSL3	RXFP1	ENSP00000369017	ENSP00000405841	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors	0.983
INSL3	RXFP2	ENSP00000369017	ENSP00000298386	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3)	0.997
INSL3	RXFP3	ENSP00000369017	ENSP00000328708	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors	0.733
INSL3	RXFP4	ENSP00000369017	ENSP00000357301	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family	0.709
INSL4	INSL3	ENSP00000239316	ENSP00000369017	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	0.745
INSL4	INSL5	ENSP00000239316	ENSP00000302724	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	0.789
INSL4	RLN1	ENSP00000239316	ENSP00000223862	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family	0.754
INSL4	RLN2	ENSP00000239316	ENSP00000371040	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands	0.725
INSL4	RLN3	ENSP00000239316	ENSP00000397415	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family	0.734
INSL4	RXFP1	ENSP00000239316	ENSP00000405841	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors	0.669
INSL4	RXFP2	ENSP00000239316	ENSP00000298386	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3)	0.643
INSL4	RXFP3	ENSP00000239316	ENSP00000328708	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors	0.649
INSL4	RXFP4	ENSP00000239316	ENSP00000357301	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family	0.669
INSL5	INSL3	ENSP00000302724	ENSP00000369017	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	0.792
INSL5	INSL4	ENSP00000302724	ENSP00000239316	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	0.789

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