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STRINGSTRING
TPM4 TPM4 ACTG2 ACTG2 ACTA2 ACTA2 TPM2 TPM2 MYLK3 MYLK3 MYL7 MYL7 TNNT2 TNNT2 TPM3 TPM3 MYH11 MYH11 TPM1 TPM1 MYLK MYLK
"MYL7" - Myosin regulatory light chain 2, atrial isoform in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MYL7Myosin regulatory light chain 2, atrial isoform; EF-hand domain containing (175 aa)    
Predicted Functional Partners:
MYLK
Myosin light chain kinase, smooth muscle; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological [...] (1914 aa)
      
  0.990
MYH11
Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1979 aa)
      
  0.975
TNNT2
Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (298 aa)
      
 
  0.959
TPM4
Tropomyosin alpha-4 chain; Tropomyosin 4; Tropomyosins (284 aa)
      
  0.956
TPM2
Tropomyosin beta chain; Tropomyosin 2; Belongs to the tropomyosin family (284 aa)
      
  0.954
TPM1
Tropomyosin alpha-1 chain; Tropomyosin 1; Tropomyosins (284 aa)
      
  0.954
ACTA2
Actin, aortic smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family (377 aa)
      
  0.953
TPM3
Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family (285 aa)
      
  0.952
ACTG2
Actin, gamma-enteric smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa)
      
  0.946
MYLK3
Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity) (819 aa)
      
  0.936
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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