ABHD11 protein (human) - STRING database

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ABHD11

Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily (315 aa)

Predicted Functional Partners:

MAK16

0.722

TWISTNB

0.719

PAFAH2

0.693

ABHD13

0.665

UTP11L

0.663

ABHD6

0.633

NCEH1

0.625

APEH

0.586

LYPLA2

0.583

ABHD3

0.581

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD11	ABHD13	ENSP00000222800	ENSP00000365063	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Protein ABHD13; Abhydrolase domain containing 13	0.665
ABHD11	ABHD3	ENSP00000222800	ENSP00000289119	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	0.581
ABHD11	ABHD6	ENSP00000222800	ENSP00000420315	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity); Belongs to the AB hydrolase superfamily	0.633
ABHD11	APEH	ENSP00000222800	ENSP00000296456	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family	0.586
ABHD11	LYPLA2	ENSP00000222800	ENSP00000363638	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity)	0.583
ABHD11	MAK16	ENSP00000222800	ENSP00000353246	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Protein MAK16 homolog; RNA binding motif containing	0.722
ABHD11	NCEH1	ENSP00000222800	ENSP00000442464	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	0.625
ABHD11	PAFAH2	ENSP00000222800	ENSP00000363400	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme	0.693
ABHD11	TWISTNB	ENSP00000222800	ENSP00000222567	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters; Belongs to the eukaryotic RPA43 RNA polymerase subunit family	0.719
ABHD11	UTP11L	ENSP00000222800	ENSP00000362105	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA	0.663
ABHD13	ABHD11	ENSP00000365063	ENSP00000222800	Protein ABHD13; Abhydrolase domain containing 13	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	0.665
ABHD13	ABHD3	ENSP00000365063	ENSP00000289119	Protein ABHD13; Abhydrolase domain containing 13	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	0.570
ABHD13	ABHD6	ENSP00000365063	ENSP00000420315	Protein ABHD13; Abhydrolase domain containing 13	Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity); Belongs to the AB hydrolase superfamily	0.466
ABHD13	LYPLA2	ENSP00000365063	ENSP00000363638	Protein ABHD13; Abhydrolase domain containing 13	Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity)	0.813
ABHD13	NCEH1	ENSP00000365063	ENSP00000442464	Protein ABHD13; Abhydrolase domain containing 13	Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	0.414
ABHD13	PAFAH2	ENSP00000365063	ENSP00000363400	Protein ABHD13; Abhydrolase domain containing 13	Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme	0.491
ABHD3	ABHD11	ENSP00000289119	ENSP00000222800	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily	0.581
ABHD3	ABHD13	ENSP00000289119	ENSP00000365063	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	Protein ABHD13; Abhydrolase domain containing 13	0.570
ABHD3	ABHD6	ENSP00000289119	ENSP00000420315	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity); Belongs to the AB hydrolase superfamily	0.574
ABHD3	NCEH1	ENSP00000289119	ENSP00000442464	Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids; Abhydrolase domain containing	Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	0.401

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