| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDCA7L | ITGB8 | ENSP00000383986 | ENSP00000222573 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | 0.548 |
| CDCA7L | MACC1 | ENSP00000383986 | ENSP00000383185 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo | 0.512 |
| CDCA7L | RAPGEF5 | ENSP00000383986 | ENSP00000343656 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.755 |
| CDCA7L | SP4 | ENSP00000383986 | ENSP00000222584 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.591 |
| CDCA7L | TMEM196 | ENSP00000383986 | ENSP00000384234 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | Transmembrane protein 196 | 0.593 |
| GJA5 | SP4 | ENSP00000484552 | ENSP00000222584 | Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.714 |
| HPS3 | HPS4 | ENSP00000296051 | ENSP00000381213 | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 | 0.975 |
| HPS3 | HPS5 | ENSP00000296051 | ENSP00000265967 | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins; Belongs to the HPS5 family | 0.987 |
| HPS3 | SP4 | ENSP00000296051 | ENSP00000222584 | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.624 |
| HPS4 | HPS3 | ENSP00000381213 | ENSP00000296051 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 | 0.975 |
| HPS4 | HPS5 | ENSP00000381213 | ENSP00000265967 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins; Belongs to the HPS5 family | 0.959 |
| HPS4 | SP4 | ENSP00000381213 | ENSP00000222584 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.580 |
| HPS5 | HPS3 | ENSP00000265967 | ENSP00000296051 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins; Belongs to the HPS5 family | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 | 0.987 |
| HPS5 | HPS4 | ENSP00000265967 | ENSP00000381213 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins; Belongs to the HPS5 family | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 | 0.959 |
| HPS5 | SP4 | ENSP00000265967 | ENSP00000222584 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins; Belongs to the HPS5 family | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.607 |
| ITGB8 | CDCA7L | ENSP00000222573 | ENSP00000383986 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | 0.548 |
| ITGB8 | MACC1 | ENSP00000222573 | ENSP00000383185 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo | 0.655 |
| ITGB8 | RAPGEF5 | ENSP00000222573 | ENSP00000343656 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation | 0.520 |
| ITGB8 | SP4 | ENSP00000222573 | ENSP00000222584 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.602 |
| ITGB8 | TMEM196 | ENSP00000222573 | ENSP00000384234 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin | Transmembrane protein 196 | 0.625 |
