| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP1A1 | CYP3A43 | ENSP00000369050 | ENSP00000222382 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | 0.424 |
| CYP1A1 | FMO1 | ENSP00000369050 | ENSP00000481732 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines | 0.545 |
| CYP1A1 | FMO3 | ENSP00000369050 | ENSP00000356729 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | Dimethylaniline monooxygenase [N-oxide-forming] 3; Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds | 0.524 |
| CYP1A1 | NR1I2 | ENSP00000369050 | ENSP00000336528 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds [...] | 0.699 |
| CYP1A1 | POR | ENSP00000369050 | ENSP00000419970 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; Belongs to the NADPH--cytochrome P450 reductase family | 0.727 |
| CYP1A1 | PPIG | ENSP00000369050 | ENSP00000260970 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | Peptidyl-prolyl cis-trans isomerase G; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing; Cyclophilin peptidylprolyl isomerases | 0.900 |
| CYP1A1 | SRD5A2 | ENSP00000369050 | ENSP00000477587 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.418 |
| CYP1A1 | UGT1A4 | ENSP00000369050 | ENSP00000362508 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity) | 0.873 |
| CYP3A43 | CYP1A1 | ENSP00000222382 | ENSP00000369050 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | 0.424 |
| CYP3A43 | FMO1 | ENSP00000222382 | ENSP00000481732 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines | 0.538 |
| CYP3A43 | FMO3 | ENSP00000222382 | ENSP00000356729 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds | 0.490 |
| CYP3A43 | LSMEM2 | ENSP00000222382 | ENSP00000315081 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Leucine rich single-pass membrane protein 2 | 0.444 |
| CYP3A43 | NR1I2 | ENSP00000222382 | ENSP00000336528 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds [...] | 0.531 |
| CYP3A43 | POR | ENSP00000222382 | ENSP00000419970 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; Belongs to the NADPH--cytochrome P450 reductase family | 0.552 |
| CYP3A43 | PPIG | ENSP00000222382 | ENSP00000260970 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | Peptidyl-prolyl cis-trans isomerase G; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing; Cyclophilin peptidylprolyl isomerases | 0.568 |
| CYP3A43 | SRD5A2 | ENSP00000222382 | ENSP00000477587 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.432 |
| CYP3A43 | TBC1D29 | ENSP00000222382 | ENSP00000462799 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | TBC1 domain family member 29 | 0.424 |
| CYP3A43 | UGT1A4 | ENSP00000222382 | ENSP00000362508 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity) | 0.413 |
| FMO1 | CYP1A1 | ENSP00000481732 | ENSP00000369050 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics | 0.545 |
| FMO1 | CYP3A43 | ENSP00000481732 | ENSP00000222382 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 | 0.538 |
