node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC6 | ARRDC2 | ENSP00000444156 | ENSP00000222250 | Armadillo repeat containing 6 | Arrestin domain containing 2; Belongs to the arrestin family | 0.550 |
ARMC6 | KLHDC4 | ENSP00000444156 | ENSP00000270583 | Armadillo repeat containing 6 | Kelch domain containing 4 | 0.728 |
ARRDC2 | ARMC6 | ENSP00000222250 | ENSP00000444156 | Arrestin domain containing 2; Belongs to the arrestin family | Armadillo repeat containing 6 | 0.550 |
ARRDC2 | DSCR3 | ENSP00000222250 | ENSP00000311399 | Arrestin domain containing 2; Belongs to the arrestin family | Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.725 |
ARRDC2 | KLHDC4 | ENSP00000222250 | ENSP00000270583 | Arrestin domain containing 2; Belongs to the arrestin family | Kelch domain containing 4 | 0.582 |
ARRDC2 | NEDD4 | ENSP00000222250 | ENSP00000424827 | Arrestin domain containing 2; Belongs to the arrestin family | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | 0.600 |
ARRDC2 | OTP | ENSP00000222250 | ENSP00000302814 | Arrestin domain containing 2; Belongs to the arrestin family | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | 0.570 |
ARRDC2 | PTPN11 | ENSP00000222250 | ENSP00000340944 | Arrestin domain containing 2; Belongs to the arrestin family | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.559 |
ARRDC2 | PTPN6 | ENSP00000222250 | ENSP00000391592 | Arrestin domain containing 2; Belongs to the arrestin family | Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Protein tyrosine phosphatases, non-receptor type | 0.584 |
ARRDC2 | VPS26A | ENSP00000222250 | ENSP00000362480 | Arrestin domain containing 2; Belongs to the arrestin family | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.656 |
ARRDC2 | VPS26B | ENSP00000222250 | ENSP00000281187 | Arrestin domain containing 2; Belongs to the arrestin family | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.707 |
ARRDC2 | WWP1 | ENSP00000222250 | ENSP00000427793 | Arrestin domain containing 2; Belongs to the arrestin family | NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to [...] | 0.698 |
DSCR3 | ARRDC2 | ENSP00000311399 | ENSP00000222250 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Arrestin domain containing 2; Belongs to the arrestin family | 0.725 |
DSCR3 | VPS26A | ENSP00000311399 | ENSP00000362480 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.405 |
KLHDC4 | ARMC6 | ENSP00000270583 | ENSP00000444156 | Kelch domain containing 4 | Armadillo repeat containing 6 | 0.728 |
KLHDC4 | ARRDC2 | ENSP00000270583 | ENSP00000222250 | Kelch domain containing 4 | Arrestin domain containing 2; Belongs to the arrestin family | 0.582 |
NEDD4 | ARRDC2 | ENSP00000424827 | ENSP00000222250 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | Arrestin domain containing 2; Belongs to the arrestin family | 0.600 |
NEDD4 | WWP1 | ENSP00000424827 | ENSP00000427793 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to [...] | 0.928 |
OTP | ARRDC2 | ENSP00000302814 | ENSP00000222250 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Arrestin domain containing 2; Belongs to the arrestin family | 0.570 |
PTPN11 | ARRDC2 | ENSP00000340944 | ENSP00000222250 | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | Arrestin domain containing 2; Belongs to the arrestin family | 0.559 |