| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BBOX1 | FSD1 | ENSP00000263182 | ENSP00000221856 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.487 |
| BCL7A | FSD1 | ENSP00000445868 | ENSP00000221856 | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.647 |
| BCL7A | MARK1 | ENSP00000445868 | ENSP00000483424 | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt sig [...] | 0.445 |
| BCL7A | SCRN1 | ENSP00000445868 | ENSP00000388942 | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity) | 0.685 |
| CDK5 | FSD1 | ENSP00000419782 | ENSP00000221856 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.623 |
| EMR2 | FSD1 | ENSP00000319883 | ENSP00000221856 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.754 |
| ENSG00000270011 | FSD1 | ENSP00000415070 | ENSP00000221856 | ZNF559-ZNF177 readthrough; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.572 |
| FSD1 | BBOX1 | ENSP00000221856 | ENSP00000263182 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.487 |
| FSD1 | BCL7A | ENSP00000221856 | ENSP00000445868 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex | 0.647 |
| FSD1 | CDK5 | ENSP00000221856 | ENSP00000419782 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | 0.623 |
| FSD1 | EMR2 | ENSP00000221856 | ENSP00000319883 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.754 |
| FSD1 | ENSG00000270011 | ENSP00000221856 | ENSP00000415070 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | ZNF559-ZNF177 readthrough; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.572 |
| FSD1 | GSTZ1 | ENSP00000221856 | ENSP00000216465 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid; Soluble glutathione S-transferases | 0.496 |
| FSD1 | MARK1 | ENSP00000221856 | ENSP00000483424 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt sig [...] | 0.541 |
| FSD1 | SCRN1 | ENSP00000221856 | ENSP00000388942 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity) | 0.682 |
| FSD1 | TUBG1 | ENSP00000221856 | ENSP00000251413 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation; Tubulins | 0.537 |
| FSD1 | ZNF177 | ENSP00000221856 | ENSP00000468531 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | Zinc finger protein 177; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.573 |
| GSTZ1 | FSD1 | ENSP00000216465 | ENSP00000221856 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid; Soluble glutathione S-transferases | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.496 |
| MARK1 | BCL7A | ENSP00000483424 | ENSP00000445868 | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt sig [...] | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex | 0.445 |
| MARK1 | FSD1 | ENSP00000483424 | ENSP00000221856 | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt sig [...] | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing | 0.541 |
