• Version:
  • 11.0 [archived version]
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PIWIL2 PIWIL2 DMWD DMWD RSPH1 RSPH1 RSPH9 RSPH9 BHMG1 BHMG1 RSPH6A RSPH6A RSPH10B RSPH10B RSPH3 RSPH3 PHF12 PHF12 MAATS1 MAATS1 RSU1 RSU1
"RSPH6A" - Radial spoke head 6 homolog A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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Experiments
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Textmining
[Homology]
Score
RSPH6ARadial spoke head 6 homolog A; Belongs to the flagellar radial spoke RSP4/6 family (717 aa)    
Predicted Functional Partners:
RSPH9
Radial spoke head 9 homolog (306 aa)
     
   
  0.941
RSPH3
Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia; Belongs to the flagellar radial spoke RSP3 family (560 aa)
     
   
  0.866
DMWD
Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing (674 aa)
     
   
  0.813
RSU1
Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (277 aa)
     
   
  0.809
RSPH1
Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes (309 aa)
     
   
  0.599
MAATS1
Cilia- and flagella-associated protein 91; May regulate cilium motility through its role in the assembly of the axonemal radial spokes (767 aa)
     
   
  0.587
PHF12
PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA (1004 aa)
           
  0.587
RSPH10B
Radial spoke head 10 homolog B (870 aa)
     
   
  0.587
PIWIL2
Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent re [...] (973 aa)
           
  0.583
BHMG1
Basic helix-loop-helix and HMG box domain-containing protein 1 (638 aa)
           
  0.571
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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