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  • 11.0 [archived version]
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C6 C6 TBC1D7 TBC1D7 CREBL2 CREBL2 CEACAM16 CEACAM16 MS4A15 MS4A15 PPP1R37 PPP1R37 MANSC1 MANSC1 PPM1N PPM1N ZMIZ2 ZMIZ2 FXYD2 FXYD2 PTGR1 PTGR1
"PPP1R37" - Protein phosphatase 1 regulatory subunit 37 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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PPP1R37Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family (691 aa)    
Predicted Functional Partners:
MS4A15
Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains (240 aa)
           
  0.579
PPM1N
Protein phosphatase, Mg2+/Mn2+ dependent 1N (430 aa)
     
   
  0.573
C6
Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Complement system (934 aa)
           
  0.499
MANSC1
MANSC domain containing 1 (431 aa)
           
  0.495
ZMIZ2
Zinc finger MIZ domain-containing protein 2; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors; Zinc fingers MIZ-type (920 aa)
     
   
  0.448
TBC1D7
TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...] (293 aa)
           
  0.444
CREBL2
cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily (120 aa)
           
  0.440
CEACAM16
Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family (425 aa)
           
  0.437
FXYD2
Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase; Belongs to the FXYD family (66 aa)
           
  0.426
PTGR1
Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (329 aa)
           
  0.424
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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