| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BLK | FAM167A | ENSP00000259089 | ENSP00000284486 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | 0.851 |
| BLK | MTMR8 | ENSP00000259089 | ENSP00000363985 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | 0.595 |
| BLK | MTMR9 | ENSP00000259089 | ENSP00000221086 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.554 |
| BLK | XKR6 | ENSP00000259089 | ENSP00000416707 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | XK-related protein 6; XK related family; Belongs to the XK family | 0.550 |
| CDA | MTMR6 | ENSP00000364212 | ENSP00000371221 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.552 |
| CDA | MTMR9 | ENSP00000364212 | ENSP00000221086 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.747 |
| CTSE | MTMR6 | ENSP00000350911 | ENSP00000371221 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.710 |
| CTSE | MTMR9 | ENSP00000350911 | ENSP00000221086 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.679 |
| FAM167A | BLK | ENSP00000284486 | ENSP00000259089 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | 0.851 |
| FAM167A | MTMR7 | ENSP00000284486 | ENSP00000180173 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.719 |
| FAM167A | MTMR8 | ENSP00000284486 | ENSP00000363985 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | 0.416 |
| FAM167A | MTMR9 | ENSP00000284486 | ENSP00000221086 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.753 |
| FAM167A | XKR6 | ENSP00000284486 | ENSP00000416707 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | XK-related protein 6; XK related family; Belongs to the XK family | 0.860 |
| MTMR6 | CDA | ENSP00000371221 | ENSP00000364212 | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.552 |
| MTMR6 | CTSE | ENSP00000371221 | ENSP00000350911 | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | 0.710 |
| MTMR6 | MTMR7 | ENSP00000371221 | ENSP00000180173 | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.720 |
| MTMR6 | MTMR9 | ENSP00000371221 | ENSP00000221086 | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.987 |
| MTMR7 | FAM167A | ENSP00000180173 | ENSP00000284486 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | 0.719 |
| MTMR7 | MTMR6 | ENSP00000180173 | ENSP00000371221 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.720 |
| MTMR7 | MTMR8 | ENSP00000180173 | ENSP00000363985 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | 0.828 |
