DNAJC17 protein (human) - STRING database

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DNAJC17

DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins (304 aa)

Predicted Functional Partners:

RBMX2

0.870

CDC5L

0.837

C1orf123

0.808

RPUSD2

0.799

GCHFR

0.731

C12orf10

0.723

HSPA14

0.705

DNAJC6

0.702

RMDN3

0.670

DNAJC2

0.665

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf10	DNAJC17	ENSP00000267103	ENSP00000220496	UPF0160 protein MYG1, mitochondrial; Chromosome 12 open reading frame 10	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.723
C1orf123	DNAJC17	ENSP00000294360	ENSP00000220496	UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.808
CDC5L	DNAJC17	ENSP00000360532	ENSP00000220496	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.837
CDC5L	DNAJC2	ENSP00000360532	ENSP00000368565	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	0.458
CDC5L	RBMX2	ENSP00000360532	ENSP00000339090	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	RNA binding motif protein, X-linked 2	0.878
DNAJC17	C12orf10	ENSP00000220496	ENSP00000267103	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	UPF0160 protein MYG1, mitochondrial; Chromosome 12 open reading frame 10	0.723
DNAJC17	C1orf123	ENSP00000220496	ENSP00000294360	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family	0.808
DNAJC17	CDC5L	ENSP00000220496	ENSP00000360532	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.837
DNAJC17	DNAJC2	ENSP00000220496	ENSP00000368565	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	0.665
DNAJC17	DNAJC6	ENSP00000220496	ENSP00000360108	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.702
DNAJC17	GCHFR	ENSP00000220496	ENSP00000260447	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine	0.731
DNAJC17	HSPA14	ENSP00000220496	ENSP00000367623	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	0.705
DNAJC17	RBMX2	ENSP00000220496	ENSP00000339090	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	RNA binding motif protein, X-linked 2	0.870
DNAJC17	RMDN3	ENSP00000220496	ENSP00000260385	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis; Belongs to the RMDN family	0.670
DNAJC17	RPUSD2	ENSP00000220496	ENSP00000323288	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	RNA pseudouridylate synthase domain containing 2	0.799
DNAJC2	CDC5L	ENSP00000368565	ENSP00000360532	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.458
DNAJC2	DNAJC17	ENSP00000368565	ENSP00000220496	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.665
DNAJC2	DNAJC6	ENSP00000368565	ENSP00000360108	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.746
DNAJC2	HSPA14	ENSP00000368565	ENSP00000367623	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruited at hist [...]	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	0.993
DNAJC6	DNAJC17	ENSP00000360108	ENSP00000220496	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.702

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