node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALU | CHGB | ENSP00000438248 | ENSP00000368244 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.900 |
CALU | CST3 | ENSP00000438248 | ENSP00000381448 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | 0.900 |
CALU | FAM20C | ENSP00000438248 | ENSP00000322323 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.933 |
CALU | MEN1 | ENSP00000438248 | ENSP00000337088 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.900 |
CALU | PENK | ENSP00000438248 | ENSP00000324248 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family | 0.900 |
CALU | SCG2 | ENSP00000438248 | ENSP00000304133 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Secretogranin-2; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides; Granins | 0.900 |
CALU | SCG3 | ENSP00000438248 | ENSP00000220478 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Secretogranin-3; Secretogranin III; Granins | 0.916 |
CALU | SPARCL1 | ENSP00000438248 | ENSP00000414856 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | SPARC-like protein 1; SPARC family | 0.902 |
CALU | VGF | ENSP00000438248 | ENSP00000249330 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins | 0.902 |
CHGA | CHGB | ENSP00000216492 | ENSP00000368244 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.943 |
CHGA | MEN1 | ENSP00000216492 | ENSP00000337088 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.666 |
CHGA | PENK | ENSP00000216492 | ENSP00000324248 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family | 0.562 |
CHGA | SCG2 | ENSP00000216492 | ENSP00000304133 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-2; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides; Granins | 0.860 |
CHGA | SCG3 | ENSP00000216492 | ENSP00000220478 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-3; Secretogranin III; Granins | 0.979 |
CHGA | VGF | ENSP00000216492 | ENSP00000249330 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins | 0.578 |
CHGB | CALU | ENSP00000368244 | ENSP00000438248 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity); Belongs to the CREC family | 0.900 |
CHGB | CHGA | ENSP00000368244 | ENSP00000216492 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.943 |
CHGB | CST3 | ENSP00000368244 | ENSP00000381448 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | 0.928 |
CHGB | FAM20C | ENSP00000368244 | ENSP00000322323 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.920 |
CHGB | MEN1 | ENSP00000368244 | ENSP00000337088 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.917 |