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  • 11.0 [archived version]
STRINGSTRING
SCUBE2 SCUBE2 ENDOV ENDOV PTPDC1 PTPDC1 ITSN2 ITSN2 RSU1 RSU1 RASL12 RASL12 PFDN1 PFDN1 RNPEP RNPEP EIF2AK1 EIF2AK1 ARL5A ARL5A ARHGEF17 ARHGEF17
"RASL12" - Ras-like protein family member 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RASL12Ras-like protein family member 12; RAS type GTPase family (266 aa)    
Predicted Functional Partners:
EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (630 aa)
           
  0.688
ARL5A
ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity; ARF GTPase family (179 aa)
     
   
  0.651
ENDOV
Endonuclease V; Endoribonuclease that specifically cleaves inosine- containing RNAs- cleaves RNA at the second phosphodiester bond 3’ to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5’-IIUI-3’ and 5’- UIUU-3’. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear- it could either play a regulatory role in edited RNAs, or be involve [...] (282 aa)
           
  0.643
ITSN2
Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes; C2 domain containing (1697 aa)
     
 
  0.608
PFDN1
Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits (122 aa)
           
  0.591
PTPDC1
Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance; CDC14 phosphatases (808 aa)
       
 
  0.568
RSU1
Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (277 aa)
       
 
  0.536
ARHGEF17
Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases (2063 aa)
     
 
  0.529
RNPEP
Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity) (650 aa)
       
 
  0.519
SCUBE2
Signal peptide, CUB domain and EGF like domain containing 2 (971 aa)
     
 
  0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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