node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF17 | RASL12 | ENSP00000263674 | ENSP00000220062 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | Ras-like protein family member 12; RAS type GTPase family | 0.529 |
ARL5A | RASL12 | ENSP00000295087 | ENSP00000220062 | ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity; ARF GTPase family | Ras-like protein family member 12; RAS type GTPase family | 0.651 |
EIF2AK1 | RASL12 | ENSP00000199389 | ENSP00000220062 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Ras-like protein family member 12; RAS type GTPase family | 0.688 |
ENDOV | RASL12 | ENSP00000429190 | ENSP00000220062 | Endonuclease V; Endoribonuclease that specifically cleaves inosine- containing RNAs- cleaves RNA at the second phosphodiester bond 3’ to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5’-IIUI-3’ and 5’- UIUU-3’. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear- it could either play a regulatory role in edited RNAs, or be involve [...] | Ras-like protein family member 12; RAS type GTPase family | 0.643 |
ITSN2 | RASL12 | ENSP00000347244 | ENSP00000220062 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes; C2 domain containing | Ras-like protein family member 12; RAS type GTPase family | 0.608 |
PFDN1 | RASL12 | ENSP00000261813 | ENSP00000220062 | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | Ras-like protein family member 12; RAS type GTPase family | 0.591 |
PFDN1 | RNPEP | ENSP00000261813 | ENSP00000295640 | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity) | 0.564 |
PTPDC1 | RASL12 | ENSP00000477817 | ENSP00000220062 | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance; CDC14 phosphatases | Ras-like protein family member 12; RAS type GTPase family | 0.568 |
RASL12 | ARHGEF17 | ENSP00000220062 | ENSP00000263674 | Ras-like protein family member 12; RAS type GTPase family | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | 0.529 |
RASL12 | ARL5A | ENSP00000220062 | ENSP00000295087 | Ras-like protein family member 12; RAS type GTPase family | ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity; ARF GTPase family | 0.651 |
RASL12 | EIF2AK1 | ENSP00000220062 | ENSP00000199389 | Ras-like protein family member 12; RAS type GTPase family | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | 0.688 |
RASL12 | ENDOV | ENSP00000220062 | ENSP00000429190 | Ras-like protein family member 12; RAS type GTPase family | Endonuclease V; Endoribonuclease that specifically cleaves inosine- containing RNAs- cleaves RNA at the second phosphodiester bond 3’ to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5’-IIUI-3’ and 5’- UIUU-3’. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear- it could either play a regulatory role in edited RNAs, or be involve [...] | 0.643 |
RASL12 | ITSN2 | ENSP00000220062 | ENSP00000347244 | Ras-like protein family member 12; RAS type GTPase family | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes; C2 domain containing | 0.608 |
RASL12 | PFDN1 | ENSP00000220062 | ENSP00000261813 | Ras-like protein family member 12; RAS type GTPase family | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | 0.591 |
RASL12 | PTPDC1 | ENSP00000220062 | ENSP00000477817 | Ras-like protein family member 12; RAS type GTPase family | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance; CDC14 phosphatases | 0.568 |
RASL12 | RNPEP | ENSP00000220062 | ENSP00000295640 | Ras-like protein family member 12; RAS type GTPase family | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity) | 0.519 |
RASL12 | RSU1 | ENSP00000220062 | ENSP00000367154 | Ras-like protein family member 12; RAS type GTPase family | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.536 |
RASL12 | SCUBE2 | ENSP00000220062 | ENSP00000429969 | Ras-like protein family member 12; RAS type GTPase family | Signal peptide, CUB domain and EGF like domain containing 2 | 0.516 |
RNPEP | PFDN1 | ENSP00000295640 | ENSP00000261813 | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity) | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | 0.564 |
RNPEP | RASL12 | ENSP00000295640 | ENSP00000220062 | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity) | Ras-like protein family member 12; RAS type GTPase family | 0.519 |